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首页> 外文期刊>Journal of bacteriology >Involvement of heat shock proteins in bacteriophage Mu development.
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Involvement of heat shock proteins in bacteriophage Mu development.

机译：热休克蛋白参与噬菌体Mu的发育。

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摘要

Growth of bacteriophage Mu was severely inhibited at elevated temperature in mutants defective in the heat shock genes dnaK, groEL, and groES and in the rpoH (htpR) regulatory mutant, but not in mutants defective in the heat shock genes dnaJ or grpE; growth of a mutant of Mu deficient in functions encoded in the accessory region of the Mu genome was inhibited in the latter two host mutants. Phage production in the dnaJ mutant was restored by growth in low-salt medium. The stage in Mu development primarily affected in all except the groE mutants was phage late transcription. In contrast, the groE mutants did not support growth of Mu at any temperature; neither Mu DNA replication nor transcription was inhibited in these strains, suggesting that groE is required for phage morphogenesis as observed with several other coliphages.
机译：在热休克基因dnaK，groEL和groES以及rpoH（htpR）调节突变体中有缺陷的突变体中，噬菌体Mu的生长在高温下受到严重抑制，但在热休克基因dnaJ或grpE中有缺陷的突变体中则没有。在后两个宿主突变体中抑制了在Mu基因组的辅助区域中编码的功能缺乏的Mu突变体的生长。 dnaJ突变体中的噬菌体生产通过在低盐培养基中的生长得以恢复。 Mu发育阶段除groE突变体外主要受所有噬菌体晚期转录的影响。相反，groE突变体在任何温度下都不支持Mu的生长。在这些菌株中，Mu DNA复制和转录均未受到抑制，这表明与其他几种噬菌体相比，groE是噬菌体形态发生所必需的。

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