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首页> 外文期刊>Journal of bacteriology >Multiple Regulators Control Expression of the Entner-Doudoroff Aldolase (Eda) of Escherichia coli
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Multiple Regulators Control Expression of the Entner-Doudoroff Aldolase (Eda) of Escherichia coli

机译：多种调节剂控制大肠杆菌Enter-Doudoroff Aldolase（Eda）的表达

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The Escherichia coli eda gene, which encodes the Entner-Doudoroff aldolase, is central to the catabolism of several sugar acids. Here, we show that Eda synthesis is induced by growth on gluconate, glucuronate, or methyl-β-d-glucuronide; phosphate limitation; and carbon starvation. Transcription of eda initiates from three promoters, designated P1, P2, and P4, each of which is responsible for induction under different growth conditions. P1 controls eda induction on gluconate and is regulated by GntR. P2 controls eda induction on glucuronate and galacturonate and is regulated by KdgR. P4 is active under conditions of phosphate starvation and is directly controlled by PhoB. In addition, CsrA activates Eda synthesis, apparently by an indirect mechanism that may be involved in the modest changes in expression level that are associated with carbon starvation. The complex regulation of eda is discussed with respect to its several physiological roles, which apparently accommodate not only sugar acid catabolism but also detoxification of metabolites that could accumulate during starvation-induced stress.
机译：编码Entner-Doudoroff醛缩酶的大肠杆菌eda 基因对于几种糖酸的分解代谢至关重要。在这里，我们显示Eda合成是通过在葡萄糖酸盐，葡萄糖醛酸盐或甲基-β-d-葡萄糖醛酸上生长而诱导的;磷酸盐限制;和碳饥饿。 eda 的转录起始于三个启动子，分别命名为P1，P2和P4，每个启动子负责在不同的生长条件下进行诱导。 P1控制葡萄糖上的 eda 诱导，并受GntR调节。 P2控制葡萄糖醛酸和半乳糖醛酸的 eda 诱导，并受KdgR的调节。 P4在磷酸盐饥饿的条件下具有活性，并由PhoB直接控制。此外，CsrA显然通过间接机制激活Eda合成，该机制可能与碳饥饿相关的表达水平的适度变化。讨论了 eda 的多种生理作用，这些作用显然不仅适应糖酸分解代谢，而且还适应饥饿引起的应激过程中积累的代谢产物的解毒。

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