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首页> 外文期刊>Journal of bacteriology >Evolution of Transcription Regulatory Genes Is Linked to Niche Specialization in the Bacterial Pathogen Streptococcus pyogenes
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Evolution of Transcription Regulatory Genes Is Linked to Niche Specialization in the Bacterial Pathogen Streptococcus pyogenes

机译：转录调控基因的进化与细菌病原化脓性链球菌的生态位专门化有关。

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Streptococcus pyogenes is a highly prevalent bacterial pathogen, most often giving rise to superficial infections at the throat or skin of its human host. Three genotype-defined subpopulations of strains exhibiting strong tropisms for either the throat or skin (specialists) or having no obvious tissue site preference (generalists) are recognized. Since the microenvironments at the throat and skin are distinct, the signal transduction pathways leading to the control of gene expression may also differ for throat versus skin strains of S. pyogenes. Two loci (mga and rofAra) encoding global regulators of virulence gene expression are positioned 300 kb apart on the genome; each contains alleles forming two major sequence clusters of ～25 to 30% divergence that are under balancing selection. Strong linkage disequilibrium is observed between sequence clusters of the transcription regulatory loci and the subpopulations of throat and skin specialists, against a background of high recombination rates among housekeeping genes. A taxonomically distinct commensal species (Streptococcus dysgalactiae subspecies equisimilus) shares highly homologous rof alleles. The findings provide strong support for a mechanism underlying niche specialization that involves orthologous replacement of regulatory genes following interspecies horizontal transfer, although the directionality of gene exchange remains unknown.
机译：化脓性链球菌是一种高度流行的细菌病原体，最常在其宿主的喉咙或皮肤上引起浅表感染。可以识别出三个基因型定义的亚群，这些亚群对喉咙或皮肤表现出强烈的向性（专科医生），或者对组织部位没有明显偏好（专科医生）。由于在喉咙和皮肤处的微环境是截然不同的，因此对于 S的喉咙和皮肤菌株，导致基因表达控制的信号转导途径也可能不同。化脓。编码毒力基因表达全局调节子的两个基因座（ mga 和 rofA / nra ）在基因组上相距300 kb;每个都包含等位基因，这些等位基因形成两个主要的序列簇，每个簇的〜25％至30％差异在平衡选择下。在看家基因之间高重组率的背景下，在转录调节基因座的序列簇与喉咙和皮肤专家的亚群之间观察到了强烈的连锁不平衡。在分类学上不同的共生物种（链球菌dysgalactiae 亚种 equisimilus ）具有高度同源的 rof 等位基因。该发现为种间水平转移后直系同源替代调控基因的生态位专业化机制提供了强有力的支持，尽管基因交换的方向仍然未知。

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