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首页> 外文期刊>Journal of bacteriology >Prokaryotic Utilization of the Twin-Arginine Translocation Pathway: a Genomic Survey
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Prokaryotic Utilization of the Twin-Arginine Translocation Pathway: a Genomic Survey

机译:双精氨酸易位途径的原核利用:基因组调查。

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The twin-arginine translocation (Tat) pathway, which has been identified in plant chloroplasts and prokaryotes, allows for the secretion of folded proteins. However, the extent to which this pathway is used among the prokaryotes is not known. By using a genomic approach, a comprehensive list of putative Tat substrates for 84 diverse prokaryotes was established. Strikingly, the results indicate that the Tat pathway is utilized to highly varying extents. Furthermore, while many prokaryotes use this pathway predominantly for the secretion of redox proteins, analyses of the predicted substrates suggest that certain bacteria and archaea secrete mainly nonredox proteins via the Tat pathway. While no correlation was observed between the number of Tat machinery components encoded by an organism and the number of predicted Tat substrates, it was noted that the composition of this machinery was specific to phylogenetic taxa.
机译:在植物叶绿体和原核生物中发现的双精氨酸易位(Tat)途径可分泌折叠的蛋白质。但是,该途径在原核生物中使用的程度尚不清楚。通过使用基因组方法,建立了84种不同原核生物的推定Tat底物的完整列表。令人惊讶的是,结果表明Tat途径的利用程度差异很大。此外,尽管许多原核生物主要使用该途径来氧化还原蛋白的分泌,但对预测底物的分析表明某些细菌和古细菌通过Tat途径主要分泌非氧化还原蛋白。虽然在生物体编码的Tat机器组件的数量与预测的Tat底物的数量之间未发现相关性,但应指出,该机器的组成对系统发生类群是特定的。

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