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首页> 外文期刊>Journal of bacteriology >Biosynthesis of Cryptic Lipopolysaccharide Glycoforms in Haemophilus influenzae Involves a Mechanism Similar to That Required for O-Antigen Synthesis
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Biosynthesis of Cryptic Lipopolysaccharide Glycoforms in Haemophilus influenzae Involves a Mechanism Similar to That Required for O-Antigen Synthesis

机译：流感嗜血杆菌中隐性脂多糖糖形的生物合成涉及类似于O抗原合成所需的机制

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摘要

It is generally thought that mucosal bacterial pathogens of the genera Haemophilus, Neisseria, and Moraxella elaborate lipopolysaccharide (LPS) that is fundamentally different from that of enteric organisms that express O-specific polysaccharide side chains. Haemophilus influenzae elaborates short-chain LPS that has a role in the pathogenesis of H. influenzae infections. We show that the synthesis of LPS in this organism can no longer be as clearly distinguished from that in other gram-negative bacteria that express an O antigen. We provide evidence that a region of the H. influenzae genome, the hmg locus, is involved in the synthesis of glycoforms in which tetrasaccharide units are added en bloc, not stepwise, to the normal core glycoforms, similar to the biosynthesis of an O-antigen.
机译：一般认为嗜血杆菌，奈瑟氏球菌和莫拉克氏菌属的粘膜细菌病原菌与脂多糖的根本区别在于表达O特异性多糖侧链的肠道生物。 流感嗜血杆菌阐述了在 H发病机理中起作用的短链LPS。流感感染。我们表明，在这种生物体中LPS的合成不再能够与表达O抗原的其他革兰氏阴性细菌中的区分清楚。我们提供证据证明 H区域。流感基因组（ hmg 位点）参与糖型的合成，在该糖型中，四糖单元整体而非逐步地添加到正常核心糖型中，类似于O的生物合成-抗原。

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