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首页> 外文期刊>Journal of bacteriology >Conserved Filamentous Prophage in Escherichia coli O18:K1:H7 and Yersinia pestis Biovar orientalis
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Conserved Filamentous Prophage in Escherichia coli O18:K1:H7 and Yersinia pestis Biovar orientalis

机译:大肠杆菌O18:K1:H7和鼠疫耶尔森菌中保守的丝状噬菌体

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Microbial virulence is known to emerge by horizontal gene transfer mechanisms. Here we describe the discovery of a novel filamentous prophage, designated CUS-1, which is integrated into the chromosomal dif homologue of the high-virulence clone Escherichia coli O18:K1:H7. An homologous chromosomal element (CUS-2) in Yersinia pestis biovar orientalis is integrated at the same relative location as CUS-1; both lysogenic E. coli and Y. pestis strains produce particles with properties expected of single-stranded DNA virions. CUSφ is epidemiologically correlated with the emergence of K1 strains with increased virulence and with the Y. pestis biovar responsible for the current (third) plague pandemic.
机译:已知通过水平基因转移机制会出现微生物毒力。在这里,我们描述了一种新型丝状噬菌体CUS-1的发现,该噬菌体被整合到高毒力克隆大肠杆菌 O18:K1的染色体 dif 同源物中: H7。鼠疫耶尔森氏菌东方侧柏的同源染色体元件(CUS-2)整合在与CUS-1相同的相对位置;都是溶原性的。大肠菌 Y。瘟疫菌株可产生具有单链DNA病毒体预期特性的颗粒。在流行病学上,CUSφ与毒力增加的K1菌株的出现和 Y相关。造成当前(第三次)鼠疫大流行的瘟疫生物变种。

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