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首页> 外文期刊>Journal of bacteriology >Transcriptional control of genes encoding CS1 pili: negative regulation by a silencer and positive regulation by Rns.
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Transcriptional control of genes encoding CS1 pili: negative regulation by a silencer and positive regulation by Rns.

机译：编码CS1菌毛的基因的转录控制：消音器的负调控和Rns的正调控。

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摘要

The adherence of enterotoxigenic Escherichia coli (ETEC) to the human small intestine is an important early event in infection. Attachment is thought to be mediated by proteinaceous structures called pili. We have investigated the regulation of expression of the genes encoding CS1 pili found on human ETEC strains and find that there are at least three promoters, P1 and P2, upstream of the coo genes, and P3, downstream of the start of cooB translation. We identified a silencer of transcription which extends over several hundred bases overlapping the cooB open reading frame. This silencer is dependent on the promoter and/or upstream region for its negative effect. The DNA binding protein H-NS is a repressor of coo transcription that acts in the same region as the silencer, so it is possible that H-NS is involved in this silencing. Rns, a member of the AraC family, positively regulates transcription of the coo operon and relieves the silencing of CS1 expression.
机译：肠毒素大肠杆菌（ETEC）对人小肠的粘附是感染的重要早期事件。附着被认为是由称为菌毛的蛋白质结构介导的。我们研究了在人类ETEC菌株上发现的编码CS1菌毛的基因的表达调控，发现在cooB翻译的上游至少有三个启动子P1和P2，在cooB翻译开始的下游有P3。我们确定了转录的沉默子，其延伸超过数百个与cooB开放阅读框重叠的碱基。该消音剂的负面作用取决于启动子和/或上游区域。 DNA结合蛋白H-NS是coo转录的阻遏物，在沉默子的同一区域发挥作用，因此H-NS可能参与了这种沉默。 Rns是AraC家族的成员，可以积极调节coo操纵子的转录并减轻CS1表达的沉默。

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