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首页> 外文期刊>Journal of bacteriology >The Wide-Domain Carbon Catabolite Repressor CreA Indirectly Controls Expression of the Aspergillus nidulans xlnBGene, Encoding the Acidic Endo-β-(1,4)-Xylanase X24
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The Wide-Domain Carbon Catabolite Repressor CreA Indirectly Controls Expression of the Aspergillus nidulans xlnBGene, Encoding the Acidic Endo-β-(1,4)-Xylanase X24

机译：宽域碳分解代谢阻遏物CreA间接控制构巢曲霉xlnB基因的表达，编码酸性内切-β-（1,4）-木聚糖酶X24

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摘要

The Aspergillus nidulans xlnB gene, which encodes the acidic endo-β-(1,4)-xylanase X24, is expressed when xylose is present as the sole carbon source and repressed in the presence of glucose. That the mutation creAd30results in considerably elevated levels of xlnB mRNA indicates a role for the wide-domain repressor CreA in the repression of xlnB promoter (xlnBp) activity. Functional analyses of xlnBp::goxC reporter constructs show that none of the four CreA consensus target sites identified in xlnBp are functional in vivo. The CreA repressor is thus likely to exert carbon catabolite repression via an indirect mechanism rather than to influence xlnB expression by acting directly on xlnB.
机译：当木糖作为唯一碳源时，表达 nidulans xlnB 基因，该基因编码酸性内切β-（1,4）-木聚糖酶X 24 。在葡萄糖存在下被抑制。突变 creA d 30 导致 xlnB mRNA水平显着升高，这表明宽域阻遏物CreA在抑制< em> xlnB 启动子（ xlnBp ）活性。对 xlnBp :: goxC 报告基因构建体的功能分析表明，在 xlnBp 中鉴定出的四个CreA共有靶位点在体内均无功能。因此，CreA阻遏物可能通过间接机制抑制碳代谢物，而不是直接作用于 xlnB 来影响 xlnB 的表达。

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