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首页> 外文期刊>Journal of bacteriology >Sequence Analysis of the Staphylococcus aureus srrAB Loci Reveals that Truncation of srrA Affects Growth and Virulence Factor Expression
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Sequence Analysis of the Staphylococcus aureus srrAB Loci Reveals that Truncation of srrA Affects Growth and Virulence Factor Expression

机译:金黄色葡萄球菌srrAB基因座的序列分析表明srrA的截短影响生长和毒力因子的表达

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摘要

The SrrAB system regulates metabolism and virulence factors in Staphylococcus aureus. We sequenced the srrAB loci of 21 isolates and performed a phylogenetic analysis. Vaginal and bovine isolates clustered together, while skin isolates were genetically diverse. Few nucleotide polymorphisms were observed, and most were synonymous. Two strains (N2 and N19) with N-terminal truncations in SrrA displayed defects in growth and abnormally upregulated virulence factor expression under low-oxygen conditions.
机译:SrrAB系统调节金黄色葡萄球菌的代谢和毒力因子。我们对21个分离株的 srrAB 基因座进行了测序,并进行了系统发育分析。阴道分离物和牛分离物聚集在一起,而皮肤分离物在遗传上是多样的。观察到很少的核苷酸多态性,并且大多数是同义的。在低氧条件下,SrrA中具有N端截短的两个菌株(N2和N19)显示出生长缺陷和毒力因子表达异常上调。

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