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首页> 外文期刊>Journal of bacteriology >Characterization of a Truncated Lipoarabinomannan from the Actinomycete Turicella otitidis
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Characterization of a Truncated Lipoarabinomannan from the Actinomycete Turicella otitidis

机译：截短的放线菌Turicella otitidis的Lipoabrabinomannan的表征。

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Lipoarabinomannan (LAM) lipoglycans have been characterized from a range of mycolic acid-containing actinomycetes and from the amycolate actinomycete Amycolatopsis sulphurea. To further understand the structural diversity of this family, we have characterized the lipoglycan of the otic commensal Turicella otitidis. T. otitidis LAM (TotLAM) has been determined to consist of a mannosyl phosphatidylinositol anchor unit carrying an (α 1→6)-linked mannan core and substituted with terminal-arabinosyl branches. Thus, TotLAM has a novel truncated LAM structure. Using the human monocytic THP-1 cell line, it was found that TotLAM exhibited only minimal ability to induce tumor necrosis factor alpha. These findings contribute further to our understanding of actinomycete LAM diversity and allow further speculation as to the correlation between LAM structure and the immunomodulatory activities of these lipoglycans.
机译：脂多糖阿拉伯甘露聚糖（LAM）脂多糖的特征是从一系列含有霉菌酸的放线菌和淀粉状放线菌支链淀粉硫脲。为了进一步了解该家族的结构多样性，我们对耳鼻喉科动物耳轮虫的脂多糖进行了表征。 T。已确定耳炎LAM（TotLAM）由甘露糖基磷脂酰肌醇锚定单元组成，该锚定单元带有（α1→6）连接的甘露聚糖核心，并被末端阿拉伯糖基分支取代。因此，TotLAM具有新颖的截短的LAM结构。使用人单核细胞THP-1细胞系，发现TotLAM仅表现出最小的诱导肿瘤坏死因子α的能力。这些发现进一步有助于我们对放线菌LAM多样性的理解，并允许进一步推测LAM结构与这些脂聚糖的免疫调节活性之间的相关性。

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