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首页> 外文期刊>Journal of bacteriology >Activated by Different Signals, the PhoP/PhoQ Two-Component System Differentially Regulates Metal Uptake
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Activated by Different Signals, the PhoP/PhoQ Two-Component System Differentially Regulates Metal Uptake

机译：通过不同的信号激活，PhoP / PhoQ两组分系统差异地调节金属吸收

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The PhoP/PhoQ two-component system controls several physiological and virulence functions in Salmonella enterica. This system is activated by low Mg2+, acidic pH, and antimicrobial peptides, but the biological consequences resulting from sensing multiple signals are presently unclear. Here, we report that the PhoP/PhoQ system regulates different Salmonella genes depending on whether the inducing signal is acidic pH or low Mg2+. When Salmonella experiences acidic pH, the PhoP/PhoQ system promotes Fe2+ uptake in a process that requires the response regulator RstA, activating transcription of the Fe2+ transporter gene feoB. In contrast, the PhoP-induced RstA protein did not promote feoB expression at neutral pH with low Mg2+. The PhoP/PhoQ system promotes the expression of the Mg2+ transporter mgtA gene only when activated in bacteria starved for Mg2+. This is because mgtA transcription promoted at high Mg2+ concentrations by the acidic-pH-activated PhoP protein failed to reach the mgtA coding region due to the mgtA leader region functioning as a Mg2+ sensor. Our results show that a single two-component regulatory system can regulate distinct sets of genes in response to different input signals.
机译：PhoP / PhoQ两组分系统可控制沙门氏菌的几种生理和毒力功能。低Mg 2 + ，酸性pH和抗菌肽可激活该系统，但目前尚不清楚由感测多个信号引起的生物学后果。在这里，我们报道PhoP / PhoQ系统调节不同的沙门氏菌基因，具体取决于诱导信号是酸性pH还是低Mg 2 + 。当沙门氏菌经历酸性pH时，PhoP / PhoQ系统会促进Fe 2 + 的吸收，而这一过程需要响应调节剂RstA，从而激活Fe 2+的转录转运蛋白基因 feoB 。相反，在低Mg 2 + 的中性pH值下，PhoP诱导的RstA蛋白不能促进 feoB 表达。仅当在缺乏Mg 2 + 的细菌中被激活时，PhoP / PhoQ系统才能促进Mg 2 + 转运蛋白 mgtA 基因的表达。这是因为酸性pH激活的PhoP蛋白在高Mg 2 + 浓度下促进了 mgtA 转录未能达到 mgtA 编码区的原因到 mgtA 前导区，充当Mg 2 + 传感器。我们的结果表明，一个单一的两成分调节系统可以响应不同的输入信号调节不同的基因集。

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