...
首页> 外文期刊>Journal of bacteriology >Genome of Helicobacter pylori Strain 908
【24h】

Genome of Helicobacter pylori Strain 908

机译:幽门螺杆菌908株的基因组

获取原文
   

获取外文期刊封面封底 >>

       

摘要

Helicobacter pylori is a genetically diverse and coevolved pathogen inhabiting human gastric niches and leading to a spectrum of gastric diseases in susceptible populations. We describe the genome sequence of H. pylori 908, which was originally isolated from an African patient living in France who suffered with recrudescent duodenal ulcer disease. The strain was found to be phylogenetically related to H. pylori J99, and its comparative analysis revealed several specific genome features and novel insertion-deletion and substitution events. The genome sequence revealed several strain-specific deletions and/or gain of genes exclusively present in HP908 compared with different sequenced genomes already available in the public domain. Comparative and functional genomics of HP908 and its subclones will be important in understanding genomic plasticity and the capacity to colonize and persist in a changing host environment.
机译:幽门螺杆菌(Helicobacter pylori)是一种遗传多样且共同进化的病原体,居住在人类的胃ni中,导致易感人群中的多种胃病。我们描述了 H的基因组序列。 pylori 908,最初是从一名居住在法国的非洲患者中分离出来的,该患者患有十二指肠溃疡复发性疾病。发现该菌株与 H在系统发育上相关。 pylori J99及其比较分析揭示了一些特定的基因组特征以及新颖的插入-缺失和取代事件。与已经在公共领域中获得的不同测序基因组相比,基因组序列揭示了HP908中仅存在的几种菌株特异性缺失和/或基因获得。 HP908及其亚克隆的比较基因组和功能基因组学对于理解基因组可塑性以及在不断变化的宿主环境中定植和持久生存的能力至关重要。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号