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首页> 外文期刊>Journal of bacteriology >The Sulfolobicin Genes of Sulfolobus acidocaldariusEncode Novel Antimicrobial Proteins
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The Sulfolobicin Genes of Sulfolobus acidocaldariusEncode Novel Antimicrobial Proteins

机译:Sulfolobus acidocaldarius的sulfolobicin基因编码新型抗菌蛋白。

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Crenarchaea, such as Sulfolobus acidocaldariusand Sulfolobus tokodaii, produce antimicrobial proteins called sulfolobicins. These antimicrobial proteins inhibit the growth of closely related species. Here we report the identification of the sulfolobicin-encoding genes in S. acidocaldarius. The active sulfolobicin comprises two proteins that are equipped with a classical signal sequence. These proteins are secreted by the cells and found to be membrane vesicle associated. Gene inactivation studies demonstrate that both proteins are required for the bacteriostatic antimicrobial activity. Sulfolobicins constitute a novel class of antimicrobial proteins without detectable homology to any other protein.
机译:食肉动物,如Sulfolobus acidocaldarius和Sulfolobus tokodaii,会产生称为硫磺杀菌素的抗菌蛋白。这些抗菌蛋白抑制紧密相关物种的生长。在这里,我们报告鉴定嗜酸性链球菌中的硫霉素编码基因。活性硫代抗菌素包含两个蛋白质,它们均具有经典的信号序列。这些蛋白质由细胞分泌,并与膜囊泡相关。基因失活研究表明,这两种蛋白质均具有抑菌抗菌活性。厌氧菌素构成一类新型的抗菌蛋白,与其他任何蛋白都没有可检测的同源性。

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