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首页> 外文期刊>Journal of bacteriology >hpaR, a Putative marR Family Transcriptional Regulator, Is Positively Controlled by HrpG and HrpX and Involved in the Pathogenesis, Hypersensitive Response, and Extracellular Protease Production of Xanthomonas campestris Pathovar campestris
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hpaR, a Putative marR Family Transcriptional Regulator, Is Positively Controlled by HrpG and HrpX and Involved in the Pathogenesis, Hypersensitive Response, and Extracellular Protease Production of Xanthomonas campestris Pathovar campestris

机译：hpaR，一个假定的marR家族转录调节因子，受HrpG和HrpX的正调控，并参与了Xanthomonas campestris的致病性，过敏反应和细胞外蛋白酶的产生Pathovar campestris

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摘要

The MarR family of transcriptional regulators of bacteria are involved in the regulation of many cellular processes, including pathogenesis. In this work, we have demonstrated genetically that hpaR (hpa, hrp associated), which encodes a putative MarR family regulator, is involved in the hypersensitive response (HR), pathogenicity, and extracellular protease production of the phytopathogenic bacterium Xanthomonas campestris pathovar campestris. A mutation in hpaR resulted in complete loss of virulence in the host plant cabbage, a delayed and weakened HR in the nonhost plant pepper ECW-10R, and an increase in extracellular protease production. Detection of the β-glucuronidase activity of a plasmid-driven hpaR promoter-gusA reporter revealed that the expression of hpaR is positively controlled by HrpG and HrpX and is suppressed in rich medium while being strongly induced in minimal and hrp-inducing media and inside the host. These findings indicate that hpaR belongs to the hrpG and hrpX regulon and that HrpX regulates the extracellular protease production via hpaR in X. campestris pv. campestris.
机译：细菌的转录调节子的MarR家族参与许多细胞过程的调节，包括发病机理。在这项工作中，我们从基因上证明了编码假定的MarR家族调控因子的 hpaR （ hpa ， hrp 相关）。植物致病性黄单胞菌（Xanthomonas campestris）的致病性和致病性，以及胞外蛋白酶的产生。 hpaR 中的突变导致寄主植物白菜的毒力完全丧失，非寄主植物辣椒ECW-10R的HR延迟和减弱，以及细胞外蛋白酶产量的增加。检测质粒驱动的 hpaR 启动子- gusA 报告基因的β-葡糖醛酸糖苷酶活性表明， hpaR 的表达受HrpG的正调控HrpX和HrpX在丰富的培养基中被抑制，而在最低限度的 hrp 诱导培养基中以及宿主内部被强烈诱导。这些发现表明 hpaR 属于 hrpG 和 hrpX 调节子，HrpX通过 hpaR 调节细胞外蛋白酶的产生在 X中。 Campestris pv。桔梗。

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