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首页> 外文期刊>Journal of bacteriology >Diversifying and Stabilizing Selection of Sialidase and N-Acetylneuraminate Catabolism in Mycoplasma synoviae
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Diversifying and Stabilizing Selection of Sialidase and N-Acetylneuraminate Catabolism in Mycoplasma synoviae

机译：滑膜支原体中唾液酸酶和N-乙酰神经氨酸分解代谢的多样化和稳定选择

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摘要

Sialidase activity varies widely among strains and tends to correlate with strain virulence in the avian pathogen Mycoplasma synoviae. To characterize the forms of selection acting on enzymes required for sialic acid scavenging and catabolism, the ratios of nonsynonymous (Ka) to synonymous (Ks) mutation frequency were calculated for codons in the sialidase gene of 16 strains of M. synoviae and for its nearly identical homolog in four strains of Mycoplasma gallisepticum. The Ka/Ks (ω) values for the linked genes required for nutritive N-acetylneuraminate catabolism (nanA, nagC, nanE, nagA, and nagB) from nine strains of M. synoviae were also determined. To provide context, ω was determined for all corresponding genes of 26 strains of Clostridium perfringens and Streptococcus pneumoniae. Bayesian models of sequence evolution showed that only the sialidase of M. synoviae was under significant (P < 0.001) diversifying selection, while the M. synoviae genes for N-acetylneuraminate catabolism and all genes examined from M. gallisepticum, C. perfringens, and S. pneumoniae were under neutral to stabilizing selection. Diversifying selection acting on the sialidase of M. synoviae, but not on the sialidase of M. gallisepticum or the sialidases or other enzymes essential for sialic acid scavenging in other Firmicutes, is evidence that variation in specific activity of the enzyme is perpetuated by a nonnutritive function in M. synoviae that is influenced by the genomic context of the organism.
机译：唾液酸酶活性在菌株之间变化很大，并且倾向于与禽病原体 Synoplasma synoviae 中的毒力相关。为了表征作用于唾液酸清除和分解代谢所需酶的选择形式，非同义（ K a ）与同义（ K s）的比率计算了16个 M菌株唾液酸酶基因中密码子的突变频率。滑膜病毒及其在四株鸡毒支原体中几乎相同的同源性。营养性 N <所需的连锁基因的 K a / K s （ω）值/ em>-乙酰神经氨酸分解代谢（ nanA ， nagC ， nanE ， nagA 和 nagB ）来自9个 M菌株。还确定了滑膜炎。为了提供背景，确定了产气荚膜梭状芽孢杆菌和肺炎链球菌的26个菌株的所有对应基因的ω。贝叶斯序列进化模型表明只有唾液酸酶 M。 synoviae 处于明显的（ P <0.001）多样化选择之下，而 M。 N N -乙酰神经氨酸分解代谢的突触叶基因以及所有 M基因。 gallisepticum ， C。 perfringens 和 S。肺炎处于中性至稳定选择状态。作用于 M唾液酸酶的多样化选择。滑膜病毒，但不是 M的唾液酸酶。没食子酸或唾液酸酶或其他 Firmicutes 中唾液酸清除所必需的其他酶，证明该酶比活性的变化是由于 M中的非营养功能所致。滑膜病毒受到生物基因组环境的影响。

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