Amino Acid Residues Required for Maturation, Cell Uptake, and Processing of Translation Inhibitor Microcin C

Teymur Kazakov; Anastasia Metlitskaya; Konstantin Severinov

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Amino Acid Residues Required for Maturation, Cell Uptake, and Processing of Translation Inhibitor Microcin C

机译：成熟度，细胞摄取和翻译抑制剂Microcin C加工所需的氨基酸残基

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Microcin C (McC), a peptide-nucleotide Trojan horse antibiotic, targets aspartyl-tRNA synthetase. We present the results of a systematic mutational study of the 7-amino-acid ribosomally synthesized peptide moiety of McC. Our results define amino acid positions important for McC maturation and cell uptake and processing and open the way for creation of more potent McC-based inhibitors.

机译：Microcin C（McC），一种肽核苷酸的特洛伊木马抗生素，靶向天冬氨酰tRNA合成酶。我们提出了Mc的7氨基酸核糖体合成的肽部分的系统突变研究的结果。我们的结果确定了对于McC成熟，细胞摄取和加工至关重要的氨基酸位置，并为创建更有效的基于McC的抑制剂开辟了道路。

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《Journal of bacteriology》 |2007年第5期|共5页
作者
Teymur Kazakov; Anastasia Metlitskaya; Konstantin Severinov;
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中图分类微生物学;
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1. The Escherichia coli Yej Transporter Is Required for the Uptake of Translation Inhibitor Microcin C [J] . Maria Novikova, Anastasia Metlitskaya, Kirill Datsenko, Journal of bacteriology . 2007,第22期

机译：大肠杆菌Yej转运蛋白是摄取翻译抑制剂Microcin C所必需的
2. Identification of Key Amino Acid Residues Modulating Intracellular and In vitro Microcin E492 Amyloid Formation [J] . Paulina Aguilera, Andrés Marcoleta, Pablo Lobos-Ruiz, Frontiers in Microbiology . 2016,第2期

机译：鉴定胞内和体外 Microcin E492淀粉样蛋白形成的关键氨基酸残基
3. Identification of Key Amino Acid Residues Modulating Intracellular and In vitro Microcin E492 Amyloid Formation [J] . Paulina Aguilera, Andrés Marcoleta, Pablo Lobos-Ruiz, Frontiers in Microbiology . 2016,第6期

机译：鉴定胞内和体外 Microcin E492淀粉样蛋白形成的关键氨基酸残基
4. SYSTEMS ANALYSIS OF CHO CELL METABOLISM FOR ENHANCED FED-BATCH PROCESS PERFORMANCE: IDENTIFICATION OF NOVEL GROWTH INHIBITORS AND THEIR CONTROL BY TWEAKING AMINO ACID METABOLISM [C] . Bhanu Chandra Mulukutla, Jaitashree Kale, AnaMaria Ovalle, Cell culture engineering XV . 2016

机译：CHO细胞代谢以提高补料分批过程性能的系统分析：新型生长抑制剂的鉴定及其对叔胺基酸代谢的控制
5. The DamX cell division protein of Escherichia coli: Identification of amino acid residues critical for septal localization and peptidoglycan binding. [D] . Williams, Kyle Brandon. 2010

机译：大肠杆菌的DamX细胞分裂蛋白：鉴定对间隔定位和肽聚糖结合至关重要的氨基酸残基。
6. Amino Acid Residues Required for Maturation Cell Uptake and Processing of Translation Inhibitor Microcin C [O] . Teymur Kazakov, Anastasia Metlitskaya, Konstantin Severinov 2007

机译：成熟度细胞摄取和翻译抑制剂Microcin C加工所需的氨基酸残基
7. Amino Acid Residues Required for Maturation, Cell Uptake, and Processing of Translation Inhibitor Microcin C▿ [O] . Kazakov, Teymur, Metlitskaya, Anastasia, Severinov, Konstantin 2006

机译：成熟度，细胞摄取和翻译抑制剂MicrocinC▿加工所需的氨基酸残基
8. In Vitro Uptake of Labeled Amino Acids by Red Blood Cells of Children with Protein-Calorie Malnutrition. [R] . Mikhail, M. M., Waslien, C. I., Gabr, M. K., 1974

机译：蛋白质 - 热量营养不良患儿体外红细胞体外标记氨基酸的摄取。

Amino Acid Residues Required for Maturation, Cell Uptake, and Processing of Translation Inhibitor Microcin C

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