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首页> 外文期刊>Journal of bacteriology >Expanded Roles for Multicargo and Class 1B Effector Chaperones in Type III Secretion
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Expanded Roles for Multicargo and Class 1B Effector Chaperones in Type III Secretion

机译：在III型分泌物中多货物和1B类效应伴侣的扩展作用

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Bacterial type III secretion systems (T3SS) are complex protein assemblies that mediate the secretion of protein substrates outside the cell. Type III secretion chaperones (T3SC) are always found associated with T3SS, and they serve in multiple roles to ensure that protein substrates are efficiently targeted for secretion. Bacterial pathogens with T3SS express T3SC proteins that bind effectors, a process important for effector protein delivery into eukaryotic cells during infection. In this minireview, we focus on multicargo and class 1B T3SC that associate with effectors within significant pathogens of animals and plants. As a primary role, multicargo and class 1B T3SC form homodimers and specifically bind different effectors within the cytoplasm, maintaining the effectors in a secretion-competent state. This role makes T3SC initial and central contributors to effector-mediated pathogenesis. Recent findings have greatly expanded our understanding of cellular events linked to multicargo T3SC function. New binding interactions with T3SS components have been reported in different systems, thereby implicating multicargo T3SC in critical roles beyond effector binding. Three notable interactions with the YscN, YscV, and YscQ family members are well represented in the literature. Similar T3SC interactions are reported in the putative related flagellar T3SS, suggesting that secretion mechanisms may be more similar than previously thought. The evidence implicates multicargo and class 1B T3SC in effector binding and stabilization, in addition to T3SS recruitment and docking events.
机译：细菌III型分泌系统（T3SS）是复杂的蛋白质装配体，介导细胞外蛋白质底物的分泌。总是发现III型分泌伴侣（T3SC）与T3SS相关，并且它们起着多种作用，以确保有效地靶向蛋白质底物进行分泌。具有T3SS的细菌病原体表达与效应子结合的T3SC蛋白，这是在感染过程中将效应子蛋白传递到真核细胞中的重要过程。在此小型审查中，我们重点研究与货物和重要动植物病原体中的效应子相关的多货物和1B T3SC类。作为主要作用，多货物和1B T3SC类形成同型二聚体，并特异性结合细胞质内的不同效应子，使效应子保持在分泌型状态。 T3SC的这种作用使T3SC成为效应子介导的发病机制的初始和主要贡献者。最近的发现大大扩展了我们对与多货物T3SC功能相关的细胞事件的理解。已经在不同系统中报道了与T3SS组分的新的结合相互作用，从而使多货物T3SC参与了除效应子结合以外的关键作用。与YscN，YscV和YscQ家族成员的三种显着相互作用在文献中得到了很好的体现。推测相关的鞭毛T3SS中也报道了类似的T3SC相互作用，这表明分泌机制可能比以前认为的更为相似。有证据表明，除T3SS募集和对接事件外，多货物和1B类T3SC还与效应子结合和稳定有关。

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