Pseudomonas aeruginosa MucD Regulates the Alginate Pathway through Activation of MucA Degradation via MucP Proteolytic Activity

F. Heath Damron; Hongwei D. Yu

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Pseudomonas aeruginosa MucD Regulates the Alginate Pathway through Activation of MucA Degradation via MucP Proteolytic Activity

机译：铜绿假单胞菌MucD通过MucP蛋白水解活性通过激活MucA降解来调节藻酸盐途径。

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Alginate overproduction in Pseudomonas aeruginosa can be caused by the proteolysis of the anti-sigma factor MucA regulated by the AlgW protease. Here, we show that inactivation of MucD, an HtrA/DegP homolog and alginate regulator, can bypass AlgW, leading to an atypical proteolysis of MucA that is dependent on the MucP protease.

机译：铜绿假单胞菌中藻酸盐的过量生产可能是由AlgW蛋白酶调节的抗σ因子MucA的蛋白水解引起的。在这里，我们显示灭活HtrA / DegP同源物和藻酸盐调节剂MucD可以绕过AlgW，从而导致依赖于MucP蛋白酶的MucA发生非典型蛋白水解。

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《Journal of bacteriology》 |2011年第1期|共6页
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F. Heath Damron; Hongwei D. Yu;
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1. Independent Regulation of MucD, an HtrA-Like Protease in Pseudomonas aeruginosa, and the Role of Its Proteolytic Motif in Alginate Gene Regulation [J] . Lynn F. Wood, Dennis E. Ohman Journal of bacteriology . 2006,第8期

机译：铜绿假单胞菌HtrA样蛋白酶MucD的独立调控及其蛋白水解基序在藻酸盐基因调控中的作用
2. Independent Regulation of MucD, an HtrA-Like Protease in Pseudomonas aeruginosa, and the Role of Its Proteolytic Motif in Alginate Gene Regulation [J] . Lynn F. Wood, Dennis E. Ohman Journal of bacteriology . 2006,第8期

机译：铜绿假单胞菌HtrA样蛋白酶MucD的独立调控及其蛋白水解基序在藻酸盐基因调控中的作用
3. Pseudomonas aeruginosa Regulated Intramembrane Proteolysis: Protease MucP Can Overcome Mutations in the AlgO Periplasmic Protease To Restore Alginate Production in Nonmucoid Revertants | Journal of Bacteriology [J] . Camila Delgado, Laura Florez, Ivonne Lollett, Journal of bacteriology . 2018,第16期

机译：铜绿假单胞菌调节膜内蛋白水解：蛋白酶MucP可以克服AlgO周质蛋白酶中的突变，以恢复非粘液状还原剂中的藻酸盐生产细菌学杂志
4. Proteolytically Degradable Hydrogels With Degradation-activated Fluorescent Tags For Tracking Cellular Proteolytic Activity [C] . S.H. Lee, J.S. Miller, J.L. West Society for Biomaterials Transactions 30th Annual Meeting & Exposition vol.28: New Applications and Technologies . 2005

机译：具有降解激活荧光标记的蛋白水解可降解水凝胶，用于跟踪细胞蛋白水解活性。
5. Investigating AmrZ-mediated activation of Pseudomonas aeruginosa twitching motility and alginate production. [D] . Xu, Binjie. 2015

机译：研究AmrZ介导的铜绿假单胞菌抽动运动和藻酸盐产生的激活。
6. Pseudomonas aeruginosa MucD Regulates the Alginate Pathway through Activation of MucA Degradation via MucP Proteolytic Activity [O] . F. Heath Damron, Hongwei D. Yu 2011

机译：铜绿假单胞菌MucD通过MucP蛋白水解活性激活MucA降解来调节藻酸盐途径。
7. Pseudomonas aeruginosa MucD Regulates the Alginate Pathway through Activation of MucA Degradation via MucP Proteolytic Activity ▿ [O] . Damron, F. Heath, Yu, Hongwei D. 2010

机译：铜绿假单胞菌MucD通过MucP蛋白水解活性通过激活MucA降解来调节藻酸盐途径▿

Pseudomonas aeruginosa MucD Regulates the Alginate Pathway through Activation of MucA Degradation via MucP Proteolytic Activity

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