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首页> 外文期刊>Journal of bacteriology >Variable Expression Patterns of Mycobacterium tuberculosis PE_PGRS Genes: Evidence that PE_PGRS16 and PE_PGRS26 Are Inversely Regulated In Vivo
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Variable Expression Patterns of Mycobacterium tuberculosis PE_PGRS Genes: Evidence that PE_PGRS16 and PE_PGRS26 Are Inversely Regulated In Vivo

机译:结核分枝杆菌PE_PGRS基因的可变表达模式:体内反向调节PE_PGRS16和PE_PGRS26的证据。

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摘要

Evaluation of expression of 16 PE_PGRS genes present in Mycobacterium tuberculosis under various growth conditions demonstrated constitutive expression of 7 genes, variable expression of 7 genes, and no expression of 2 genes. An inverse expression profile for genes PE_PGRS16 and PE_PGRS26 was observed to occur in macrophages and in mice infected with M. tuberculosis. Variable expression of PE_PGRS proteins could have implications for their role in the immunopathogenesis of tuberculosis.
机译:评价结核分枝杆菌在不同生长条件下存在的16种PE_PGRS基因的表达,结果表明7种基因为组成型表达,7种基因为可变表达,而2种基因均无表达。观察到基因PE_PGRS16和PE_PGRS26的逆表达谱在巨噬细胞和感染了 M的小鼠中发生。结核病。 PE_PGRS蛋白的可变表达可能对其在结核病免疫发病机制中的作用有影响。

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