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首页> 外文期刊>Journal of bacteriology >The Two-Component Regulators GacS and GacA Positively Regulate a Nonfluorescent Siderophore through the Gac/Rsm Signaling Cascade in High-Siderophore-Yielding Pseudomonas sp. Strain HYS
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The Two-Component Regulators GacS and GacA Positively Regulate a Nonfluorescent Siderophore through the Gac/Rsm Signaling Cascade in High-Siderophore-Yielding Pseudomonas sp. Strain HYS

机译：两种成分的调节剂GacS和GacA通过产生高Siderophore的假单胞菌（Pseudomonas sp。）中的Gac / Rsm信号级联，正向调节非荧光铁载体。 HYS应变

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Siderophores, which are produced to overcome iron deficiency, are believed to be closely related to the adaptability of bacteria. The high-siderophore-yielding Pseudomonas sp. strain HYS simultaneously secretes the fluorescent siderophore pyoverdine and another nonfluorescent siderophore that is a major contributor to the high siderophore yield. Transposon mutagenesis revealed siderophore-related genes, including the two-component regulators GacS/GacA and a special cluster containing four open reading frames (the nfs cluster). Deletion mutations of these genes abolished nonfluorescent-siderophore production, and expression of the nfs cluster depended on gacA, indicating that gacS-gacA may control the nonfluorescent siderophore through regulation of the nfs cluster. Furthermore, regulation of the nonfluorescent siderophore by GacS/GacA involved the Gac/Rsm pathway. In contrast, inactivation of GacS/GacA led to upregulation of the fluorescent pyoverdine. The two siderophores were secreted under different iron conditions, probably because of differential effects of GacS/GacA. The global GacS/GacA regulatory system may control iron uptake by modulating siderophore production and may enable bacteria to adapt to changing iron environments.
机译：克服铁缺乏而产生的铁载体被认为与细菌的适应性密切相关。产生高铁载体的假单胞菌。 HYS菌株同时分泌荧光铁载体吡啶酮和另一种非荧光铁载体，这是铁载体产量高的主要因素。转座子诱变揭示了铁载体相关基因，包括两个成分的调节子GacS / GacA和一个特殊的簇，其中包含四个开放阅读框（ nfs 簇）。这些基因的缺失突变消除了非荧光铁载体的产生， nfs 簇的表达取决于 gacA ，表明 gacS-gacA 可能控制了通过调节 nfs 团簇形成非荧光的铁载体。此外，GacS / GacA对非荧光铁载体的调控涉及Gac / Rsm途径。相反，GacS / GacA的失活导致荧光吡啶酮的上调。两种铁载体在不同的铁条件下分泌，可能是由于GacS / GacA的不同作用所致。全球GacS / GacA监管系统可以通过调节铁载体的生成来控制铁的吸收，并使细菌能够适应不断变化的铁环境。

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