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首页> 外文期刊>Journal of vision >Blindness produces yoked changes in V1 cortical thickness, cross-modal responses, and resting metabolism.
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Blindness produces yoked changes in V1 cortical thickness, cross-modal responses, and resting metabolism.

机译：失明会导致V1皮质厚度，交叉模式反应和静息代谢产生轭铁变化。

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Blindness alters brain structure and function, but whether these specific changes are related or independent across subjects has not been examined. We tested the hypothesis that blind individuals with thickened striate cortex (indicative of altered synaptic pruning) would show linked changes in cross-modal neural response and resting blood flow. 37 blind (55?±12 years) and 23 sighted (38?±17) participants were studied. fMRI data were collected at rest in darkness and during a semantic decision task (plausibility judgement of spoken sentences). MPRAGE, resting perfusion and DTI were also acquired. Mean cerebral blood flow (CBF), cross-modal activation to auditory sentences (BOLD %), cortical thickness, and surface area were measured within V1. Functional connectivity between V1 and somatosensory and Brocaa??s area were calculated from rest data. Volumes and fractional anisotropy (FA) of the optic and radiations, pericalcarine white matter, and splenium were obtained. We replicated prior work, finding significant differences between the sighted and blind groups in almost every measure. We then examined if there exist correlations across blind subjects in structural and functional alterations which may not be present in the sighted group. Cortical thickness was significantly correlated (and V1 surface area negatively correlated) with cross-modal activation (r=0.51), which in turn was strongly correlated with V1 perfusion at rest (r=0.47) and long-range functional connectivity with somatosensory cortex (r=0.63). Interestingly, anatomical measures of the anterior visual pathway (chiasmal volume and FA, optic radiation FA) were not correlated with these alterations. Our results provide a direct link between presumed alterations in cortical maturation in blindness that lead in turn to preserved long-range functional connections, and cross-modal representation. Further, these "compensatory" changes appear to be independent from the "degeneration" changes in the anterior visual pathway associated with damage to the neural retina.
机译：失明会改变大脑的结构和功能，但是这些特定的变化在受试者之间是相关的还是独立的，尚未得到检验。我们检验了以下假设，即具有纹状皮质增厚的盲人（表明突触修剪被改变）将显示跨模式神经反应和静息血流的相关变化。研究了37名盲人（55±12岁）和23名盲人（38±17）岁。 fMRI数据是在黑暗中休息和进行语义决策任务（口头句子的合理性判断）期间收集的。还获得了MPRAGE，静息灌注和DTI。在V1内测量平均脑血流量（CBF），跨模态激活听觉语句（BOLD％），皮质厚度和表面积。从其余数据计算出V1与体感区和Brocaa区之间的功能连通性。得到了光学和辐射，黄per肉白质和脾的体积和分数各向异性（FA）。我们重复了以前的工作，发现在几乎所有方面，有视力的人群和盲人的人群之间都存在显着差异。然后，我们检查了盲者在结构和功能改变中是否存在相关性，而在有视力的人群中可能不存在相关性。皮质厚度与交叉模式激活（r = 0.51）显着相关（且V1表面积呈负相关），而交叉模式激活又与静止时的V1灌注（r = 0.47）以及与体感皮层的远距离功能连接密切相关（ r = 0.63）。有趣的是，前视路的解剖学测量（大便​​体积和FA，视辐射FA）与这些改变无关。我们的结果提供了失明的皮质成熟的推测变化之间的直接联系，而后者又导致保留了长期的功能连接和交叉模式表示。此外，这些“补偿性”改变似乎独立于与神经视网膜损伤相关的前视觉通路中的“变性”改变。

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