首页> 外文期刊>Journal of vision >How much can we learn about the primate visual system by studying the mouse?
【24h】

How much can we learn about the primate visual system by studying the mouse?

机译:通过研究鼠标,我们可以学到多少关于灵长类动物视觉系统的信息?

获取原文
           

摘要

Studying the mouse offers unique opportunities for using genetic techniques to unravel nervous system function. But how much can we learn about the human/primate visual system by studying the mouse? Unlike human and other primates, mouse is nocturnal and its retina lacks a cone-rich fovea. Nevertheless, the structure of primate and mouse retina (and indeed all mammalian retinas) is similar. Furthermore, both the peripheral primate retina and the mouse retina are rod-dominated (95% of photoreceptors). Primate and mouse retinas contain many of the same cell types, including specific interneuron types (e.g., rod bipolar cell, AII amacrine cell, starburst amacrine cell). In this talk, I will summarize some recent findings in the mouse retina that illustrate fast and robust cone-mediated inputs to ganglion cells, suggesting that mouse and primate cone systems share functional properties. I will also describe genetic methods that reveal the structure and function of novel neural circuits in mouse retina. Studies of mouse retina will be useful for understanding general principles of neural circuit function common to all mammals and may be especially relevant for understanding the temporal properties of primate vision.
机译:研究鼠标为利用遗传技术揭示神经系统功能提供了独特的机会。但是通过研究鼠标,我们可以了解多少有关人类/灵长类动物视觉系统的信息?与人类和其他灵长类动物不同,小鼠是夜行性的,其视网膜缺乏圆锥状的中央凹。尽管如此,灵长类和小鼠视网膜(实际上是所有哺乳动物的视网膜)的结构是相似的。此外,周围的灵长类动物视网膜和小鼠视网膜都是杆状的(> 95%的感光细胞)。灵长类动物和小鼠视网膜包含许多相同的细胞类型,包括特定的中间神经元类型(例如棒状双极细胞,AII紫水晶细胞,星爆紫水晶细胞)。在本次演讲中,我将总结一些在小鼠视网膜中的最新发现,这些发现说明了神经节细胞向视锥细胞介导的快速而稳健的输入,表明小鼠和灵长类视锥系统具有共同的功能特性。我还将描述揭示小鼠视网膜中新型神经回路的结构和功能的遗传方法。对小鼠视网膜的研究将有助于理解所有哺乳动物共有的神经回路功能的一般原理,并且对于了解灵长类动物视力的时间特性可能尤其重要。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号