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首页> 外文期刊>Bulletin of the American Physical Society >APS -70th Annual Meeting of the APS Division of Fluid Dynamics- Event - Stochastic Modeling of the Clathrin-dependent and -independent Endocytic Pathways
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APS -70th Annual Meeting of the APS Division of Fluid Dynamics- Event - Stochastic Modeling of the Clathrin-dependent and -independent Endocytic Pathways

机译：APS-流体动力学APS部门第70届年会-事件-网格蛋白依赖性和非依赖性内吞途径的随机建模

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摘要

Endocytosis is one of the important processes that bioparticles use to enter the cells. During endocytosis the membrane-bound vesicles are formed by the invagination of plasma membrane as a result of interactions among many proteins and cytoskeletons. The clathrin-mediated endocytosis is one of the most significant form of endocytosis, where the dynamic assembly of clathrin-coated pits play a critical role. While herpes simplex virus-1 has recently shown to infect cell by a novel phagocytosis-like endocytic pathway where actin polymerization may facilitate the viral entry. In this work, we propose a stochastic model for both clathrin-dependent and --independent endocytic pathways based on Monte Carlo simulations. The important roles of clathrin coating and actin cytoskeleton as well as the impact of other biological parameters are studied. Our preliminary results indicate that there exist an intermediate particle size and ligand density that maximize the internalization efficiency. Below a critical size or surface ligand density, it is difficult for the entry of a single particle, which means clustering may needed for more efficient internalization. We also find that lower membrane bending rigidity may help promote the bioparticle entry.
机译：胞吞作用是生物颗粒进入细胞的重要过程之一。在胞吞过程中，由于许多蛋白质与细胞骨架之间的相互作用，质膜的内陷使膜结合的囊泡形成。网格蛋白介导的内吞作用是内吞作用的最重要形式之一，其中网格蛋白包被的凹坑的动态组装起关键作用。虽然最近显示出单纯疱疹病毒1通过一种新的吞噬作用样内吞途径感染细胞，其中肌动蛋白的聚合可以促进病毒的进入。在这项工作中，我们提出了基于蒙特卡洛模拟的网格蛋白依赖性和非依赖性细胞内吞途径的随机模型。研究了网格蛋白涂层和肌动蛋白细胞骨架的重要作用以及其他生物学参数的影响。我们的初步结果表明，存在一个中间粒径和配体密度，可最大化内化效率。低于临界尺寸或表面配体密度，单个颗粒很难进入，这意味着可能需要聚集才能更有效地内化。我们还发现较低的膜弯曲刚度可能有助于促进生物颗粒进入。

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