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首页> 外文期刊>Bulletin of the American Physical Society >APS -APS March Meeting 2017 - Event - Formation and characterization of artificial lipid bilayers on optical fibers
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APS -APS March Meeting 2017 - Event - Formation and characterization of artificial lipid bilayers on optical fibers

机译：APS -APS 2017年3月会议-事件-光纤上人造脂质双层的形成和表征

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Transports across cellular membranes are at the basis of a lot of biological processes such as the transmission of information in neurons. Their characterization is therefore of crucial interest. As they are equivalent to biological membranes, artificial lipid bilayers can be created to study membranes and transmembrane proteins properties or transmembrane transports. The aim of this work is to develop a new method for the fabrication of artificial membranes, based on the use of optical fibers as support for the bilayer, and for their characterization by fluorescence measurements. We use microfluidics on fibers to create two phospholipid monolayers that we approach close enough to form a bilayer. The membrane formation is checked using fluorescein or a fluorescent sodium probe, Tetra (tetramethylammonium) salt (sodium green), whose optical signal depends on sodium concentration.
机译：跨细胞膜的运输是许多生物学过程的基础，例如神经元中信息的传递。因此，对它们的表征至关重要。由于它们等同于生物膜，因此可以创建人造脂质双层来研究膜和跨膜蛋白的性质或跨膜转运。这项工作的目的是开发一种新的人造膜制造方法，其基础是使用光纤作为双层的载体，并通过荧光测量对其进行表征。我们在纤维上使用微流控技术来创建两个磷脂单层，我们将其接近以形成双层。使用荧光素或荧光钠探针四（四甲基铵）盐（钠绿）检查膜的形成，其光信号取决于钠浓度。

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