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首页> 外文期刊>Scientific reports. >PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer
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PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer

机译：与小细胞肺癌预后较差有关的PRC2过表达和PRC2-靶基因抑制

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Small cell lung cancer (SCLC) is a subtype of lung cancer with poor prognosis. Expression array analysis of 23 SCLC cases and 42 normal tissues revealed that EZH2 and other PRC2 members were highly expressed in SCLC. ChIP-seq for H3K27me3 suggested that genes with H3K27me3(+) in SCLC were extended not only to PRC2-target genes in ES cells but also to other target genes such as cellular adhesion-related genes. These H3K27me3(+) genes in SCLC were repressed significantly, and introduction of the most repressed gene JUB into SCLC cell line lead to growth inhibition. Shorter overall survival of clinical SCLC cases correlated to repression of JUB alone, or a set of four genes including H3K27me3(+) genes. Treatment with EZH2 inhibitors, DZNep and GSK126, resulted in growth repression of SCLC cell lines. High PRC2 expression was suggested to contribute to gene repression in SCLC, and may play a role in genesis of SCLC.
机译：小细胞肺癌（SCLC）是预后较差的肺癌的一种亚型。 23例SCLC病例和42例正常组织的表达阵列分析表明，EZH2和其他PRC2成员在SCLC中高表达。对H3K27me3的ChIP-seq表明，在SCLC中具有H3K27me3（+）的基因不仅扩展到ES细胞中的PRC2目标基因，还扩展到其他目标基因，例如细胞粘附相关基因。 SCLC中的这些H3K27me3（+）基因被显着抑制，并且将最受抑制的基因JUB引入SCLC细胞系会导致生长抑制。临床SCLC病例的总体生存期较短与单独的JUB或包括H3K27me3（+）基因在内的四个基因的抑制有关。用EZH2抑制剂DZNep和GSK126处理导致SCLC细胞系生长受到抑制。提示高PRC2表达有助于SCLC中的基因阻遏，并可能在SCLC的发生中起作用。

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