• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Scientific reports. >Imaging single chiral nanoparticles in turbid media using circular-polarization optical coherence microscopy
【24h】

Imaging single chiral nanoparticles in turbid media using circular-polarization optical coherence microscopy

机译：使用圆偏振光学相干显微镜对混浊介质中的单个手性纳米颗粒进行成像

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Optical coherence tomography (OCT) is a widely used structural imaging method. However, it has limited use in molecular imaging due to the lack of an effective contrast mechanism. Gold nanoparticles have been widely used as molecular probes for optical microcopy based on Surface Plasmon Resonance (SPR). Unfortunately, the SPR enhanced backscattering from nanoparticles is still relatively weak compared with the background signal from microscopic structures in biological tissues when imaged with OCT. Consequently, it is extremely challenging to perform OCT imaging of conventional nanoparticles in thick tissues with sensitivity comparable to that of fluorescence imaging. We have discovered and demonstrated a novel approach towards remarkable contrast enhancement, which is achieved by the use of a circular-polarization optical coherence microscopy system and 3-dimensional chiral nanostructures as contrast agents. By detecting the circular intensity differential depolarization (CIDD), we successfully acquired high quality images of single chiral nanoparticles underneath a 1-mm-thick tissue -mimicking phantom.
机译：光学相干断层扫描（OCT）是一种广泛使用的结构成像方法。然而，由于缺乏有效的对比机制，它在分子成像中的应用受到限制。金纳米粒子已被广泛用作基于表面等离子体共振（SPR）的光学显微镜的分子探针。不幸的是，与OCT成像相比，与生物组织中微观结构的背景信号相比，纳米粒子的SPR增强的反向散射仍然相对较弱。因此，在厚组织中进行常规纳米粒子的OCT成像，其灵敏度与荧光成像相当，具有极大的挑战性。我们已经发现并证明了一种新颖的方法，可以显着提高对比度，这是通过使用圆偏振光学相干显微镜系统和三维手性纳米结构作为造影剂来实现的。通过检测圆形强度微分去极化（CIDD），我们成功地在1毫米厚的组织模拟体模下获取了单个手性纳米粒子的高质量图像。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号