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首页> 外文期刊>Scientific reports. >Visualization and quantification of injury to the ciliated epithelium using quantitative flow imaging and speckle variance optical coherence tomography
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Visualization and quantification of injury to the ciliated epithelium using quantitative flow imaging and speckle variance optical coherence tomography

机译：使用定量流成像和散斑方差光学相干断层扫描对睫状上皮损伤的可视化和定量

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Mucociliary flow is an important defense mechanism in the lung to remove inhaled pathogens and pollutants. Disruption of ciliary flow can lead to respiratory infections. Multiple factors, from drugs to disease can cause an alteration in ciliary flow. However, less attention has been given to injury of the ciliated epithelium. In this study, we show how optical coherence tomography (OCT) can be used to investigate injury to the ciliated epithelium in a multi-contrast setting. We used particle tracking velocimetry (PTV-OCT) to investigate the cilia-driven flow field and 3D speckle variance imaging to investigate size and extent of injury caused to the skin of Xenopus embryos. Two types of injuries are investigated, focal injury caused by mechanical damage and diffuse injury by a calcium chloride shock. We additionally investigate injury and regeneration of cilia to calcium chloride on ex vivo mouse trachea. This work describes how OCT can be used as a tool to investigate injury and regeneration in ciliated epithelium.
机译：粘膜纤毛流动是肺中去除吸入的病原体和污染物的重要防御机制。睫状液流动中断可导致呼吸道感染。从药物到疾病的多种因素均可导致睫状肌血流改变。但是，对纤毛上皮损伤的关注较少。在这项研究中，我们展示了光学相干断层扫描（OCT）如何可用于在多对比情况下研究对纤毛纤毛的损伤。我们使用粒子跟踪测速（PTV-OCT）来研究纤毛驱动的流场，并使用3D散斑方差成像来研究对非洲爪蟾胚胎皮肤造成的损伤的大小和程度。研究了两种类型的伤害，一种是由机械损伤引起的局部损伤，另一种是由氯化钙电击引起的弥散性损伤。我们还研究了离体小鼠气管上纤毛对氯化钙的损伤和再生。这项工作描述了如何将OCT用作研究纤毛上皮损伤和再生的工具。

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