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首页> 外文期刊>Scientific reports. >A peculiar case of Campylobacter jejuni attenuated aspartate chemosensory mutant, able to cause pathology and inflammation in avian and murine model animals
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A peculiar case of Campylobacter jejuni attenuated aspartate chemosensory mutant, able to cause pathology and inflammation in avian and murine model animals

机译：空肠弯曲菌减毒天冬氨酸化学感应突变体的特例，能够在禽和鼠模型动物中引起病理和炎症

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An attenuated Campylobacter jejuni aspartate chemoreceptor ccaA mutant caused gross pathological changes despite reduced colonisation ability in animal models. In chickens, the pathological changes included connective tissue and thickening of the mesenteric fat, as well as the disintegration of the villus tips in the large intestine, whereas in mice, hepatomegaly occurred between 48–72?hours post infection and persisted for the six days of the time course. In addition, there was a significant change in the levels of IL-12p70 in mice infected with the C . jejuni ccaA mutant. CcaA isogenic mutant was hyper-invasive in cell culture and microscopic examination revealed that it had a “run” bias in its “run-and-tumble” chemotactic behaviour. The mutant cells also exhibited lower level of binding to fucosylated and higher binding to sialylated glycan structures in glycan array analysis. This study highlights the importance of investigating phenotypic changes in C . jejuni , as we have shown that specific mutants can cause pathological changes in the host, despite reduction in colonisation potential.
机译：尽管在动物模型中定植能力降低，但减毒的空肠弯曲杆菌天冬氨酸化学感受器ccaA突变体仍引起严重的病理变化。在鸡中，病理变化包括结缔组织和肠系膜脂肪增稠，以及大肠中的绒毛尖端解体，而在小鼠中，肝肿大发生在感染后48-72小时之间，并持续了六天时间课程。另外，在感染了C 2+的小鼠中，IL-12p70水平有显着变化。空肠ccaA突变体。 CcaA等基因突变体在细胞培养中具有高侵袭性，显微镜检查显示其“奔跑”的趋化行为具有“奔跑”偏差。在聚糖阵列分析中，突变细胞还表现出较低的与岩藻糖基化的结合水平和较高的与唾液酸化的聚糖结构的结合。这项研究强调了研究C型表型变化的重要性。空肠，正如我们已经表明的，尽管定植潜力降低了，特定的突变体仍可以引起宿主的病理变化。

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