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首页> 外文期刊>Scientific reports. >Non-Water-Suppressed 1 H MR Spectroscopy with Orientational Prior Knowledge Shows Potential for Separating Intra- and Extramyocellular Lipid Signals in Human Myocardium
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Non-Water-Suppressed 1 H MR Spectroscopy with Orientational Prior Knowledge Shows Potential for Separating Intra- and Extramyocellular Lipid Signals in Human Myocardium

机译：具有定向先验知识的非水抑制1 H MR光谱显示分离人心肌细胞内和细胞外脂质信号的潜力

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Conditions such as type II diabetes are linked with elevated lipid levels in the heart, and significantly increased risk of heart failure; however, metabolic processes underlying the development of cardiac disease in type II diabetes are not fully understood. Here we present a non-invasive method for in vivo investigation of cardiac lipid metabolism: namely, IVS-McPRESS. This technique uses metabolite-cycled, non-water suppressed 1H cardiac magnetic resonance spectroscopy with prospective and retrospective motion correction. High-quality IVS-McPRESS data acquired from healthy volunteers allowed us to investigate the frequency shift of extramyocellular lipid signals, which depends on the myocardial fibre orientation. Assuming consistent voxel positioning relative to myofibres, the myofibre angle with the magnetic field was derived from the voxel orientation. For separation and individual analysis of intra- and extramyocellular lipid signals, the angle myocardial fibres in the spectroscopy voxel take with the magnetic field should be within ±24.5°. Metabolite and lipid concentrations were analysed with respect to BMI. Significant correlations between BMI and unsaturated fatty acids in intramyocellular lipids, and methylene groups in extramyocellular lipids were found. The proposed IVS-McPRESS technique enables non-invasive investigation of cardiac lipid metabolism and may thus be a useful tool to study healthy and pathological conditions.
机译：II型糖尿病等疾病与心脏脂质水平升高有关，并显着增加了心力衰竭的风险;然而，对于II型糖尿病中心脏病发展的潜在代谢过程尚未完全了解。在这里，我们提出一种用于心脏脂质代谢的体内研究的非侵入性方法：即IVS-McPRESS。该技术使用代谢物循环，非水抑制的1H心脏磁共振波谱技术进行前瞻性和回顾性运动校正。从健康志愿者那里获得的高质量IVS-McPRESS数据使我们能够研究细胞外脂质信号的频移，这取决于心肌纤维的方向。假设体素相对于肌纤维的定位一致，则肌纤维与磁场的角度是从体素方向导出的。为了分离和单独分析细胞内和细胞外脂质信号，光谱体素在磁场中与心肌的夹角应在±24.5°之内。相对于BMI分析了代谢物和脂质的浓度。发现BMI与肌细胞内脂质中的不饱和脂肪酸和肌外细胞脂质中的亚甲基之间显着相关。所提出的IVS-McPRESS技术能够进行心脏脂质代谢的非侵入性研究，因此可能是研究健康和病理状况的有用工具。

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