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首页> 外文期刊>Scientific reports. >Associations between Variants in BDNF / BDNFOS Gene and Lumbar Disc Herniation Risk among Han Chinese People
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Associations between Variants in BDNF / BDNFOS Gene and Lumbar Disc Herniation Risk among Han Chinese People

机译：汉族人群BDNF / BDNFOS基因变异与腰椎间盘突出症危险性的关系

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Lumbar disc herniation (LDH) is a low back pain disorder and associated with several single nucleotide polymorphisms (SNPs). However, the role of brain-derived neurotrophic factor ( BDNF ) and BDNFOS gene in LDH susceptibility remains unknown. To examine whether the variants contribute to LDH, 7 SNPs were genotyped in 380 patients and 692 healthy controls among Han Chinese population. Multiple genetic models, stratification by age/gender and haploview analysis was used by calculating odds ratio (OR) and 95% confidence intervals (CIs). Rs11030064 in BDNFOS gene was associated with modified susceptibility for LDH at age ≤50 years but three loci (rs6265, rs11030104 and rs10767664) of BDNF gene increased LDH risk at age >50 years. Further, rs11030096 polymorphism in BDNFOS gene was associated with LDH the increased susceptibility of LDH in females. Haplotype analysis shown that haplotype “GCC” in the block (rs988712, rs7481311, and rs11030064) increased LDH risk (OR?=?1.49, 95% CI?=?1.06–2.10, p =?0.022) at age ≤50 years. However, there was no significant association between BDNF / BDNFOS gene and LDH risk in the overall before stratified analysis. For the first time, our results provide evidence on polymorphism of BDNF / BDNFOS gene associated with LDH risk in Chinese Han population.
机译：腰椎间盘突出症（LDH）是一种下背痛疾病，与几种单核苷酸多态性（SNPs）相关。然而，脑源性神经营养因子（BDNF）和BDNFOS基因在LDH易感性中的作用仍然未知。为了检查这些变体是否有助于LDH，在汉族人群中的380名患者和692名健康对照中对7个SNP进行了基因分型。通过计算比值比（OR）和95％置信区间（CIs），使用了多种遗传模型，按年龄/性别进行的分层和haploview分析。 BDNFOS基因中的Rs11030064与≤50岁时对LDH的敏感性增加有关，但BDNF基因的三个基因座（rs6265，rs11030104和rs10767664）在大于50岁时增加了LDH的风险。此外，BDNFOS基因中的rs11030096多态性与LDH与女性中LDH敏感性增加有关。单倍型分析显示，在年龄≤50岁的人群中，单倍型“ GCC”（rs988712，rs7481311和rs11030064）增加了LDH风险（OR？=？1.49，95％CI？=？1.06--2.10，p =？0.022）。但是，在进行分层分析之前，总体上BDNF / BDNFOS基因与LDH风险之间没有显着关联。我们的研究结果首次为中国汉族人群中与LDH风险相关的BDNF / BDNFOS基因多态性提供了证据。

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