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首页> 外文期刊>Journal of Medical Microbiology: An Official Journal of the Pathological Society of Great Britain and Ireland >The calcineurin inhibitor cyclosporin A exhibits synergism with antifungals against Candida parapsilosis species complex
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The calcineurin inhibitor cyclosporin A exhibits synergism with antifungals against Candida parapsilosis species complex

机译：钙碱抑制剂环孢菌素A表现出与念珠菌肺病理复合物的抗真菌的协同作用

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摘要

Candida parapsilosis complex comprises three closely related species, C. parapsilosis sensu stricto, Candida metapsilosis and Candida orthopsilosis. In the last decade, antifungal resistance to azoles and caspofungin among C. parapsilosis sensu lato strains has been considered a matter of concern worldwide. In the present study, we evaluated the synergistic potential of antifungals and the calcineurin inhibitor cyclosporin A (Cys) against planktonic and biofilms of C. parapsilosis complex from clinical sources. Susceptibility assays with amphotericin, fluconazole, voriconazole, caspofungin and Cys were performed by microdilution in accordance with Clinical and Laboratory Standards Institute guidelines. Synergy testing against planktonic cells of C. parapsilosis sensu lato strains was assessed by the chequerboard method. Combinations formed by antifungals with Cys were evaluated against mature biofilms in microtitre plates. No differences in the antifungal susceptibility pattern among species were observed, but C. parapsilosis sensu stricto strains were more susceptible to Cys than C. orthopsilosis and C. metapsilosis. Synergism between antifungals and Cys was observed in C. parapsilosis sensu lato strains. Combinations formed by antifungals and Cys were able to prevent biofilm formation and showed an inhibitory effect against mature biofilms of C. parapsilosis sensu stricto, C. metapsilosis and C. orthopsilosis. These results strengthen the potential of calcineurin inhibition as a promising approach to enhance the efficiency of antifungal drugs.
机译：Candida Parapsilosis复合体包含三种密切相关的物种，C.Parapsilosis Sensu Sticalo，Candida缺陷和念珠菌正交。在过去的十年中，抗原抑菌和Caspofungin之间的抗真菌抗肺肺病紫外线紫外线菌株被认为是全世界关注的问题。在本研究中，我们从临床来源评估了抗真菌和钙调毒素抑制剂环孢菌素A（Cys）对氏菌菌和生物膜的协同潜力。根据临床和实验室标准研究所的指导，通过微量脱离，通过微量脱离，用两性霉素，氟康唑，伏立康唑，Caspofungin和Cys进行敏感性测定。通过CHEQUERORBER方法评估对C.PARAPSILOSIS SENSU LATO紫外菌株的协同作用测试。在微量滴定板中针对成熟的生物膜评估由抗真菌组合的组合。观察到物种之间的抗真菌易感性模式没有差异，但是C.Parapsiliss Sensu严格的菌株比C. Orthopsilosis和C.Poyalsiss更容易受到Cys。在C.Parapsilosis Sensu Lato菌株中观察到抗真菌和Cys之间的协同作用。由抗真菌和Cys形成的组合能够防止生物膜形成，并对C.Parapsiliss Sensu的成熟生物膜进行抑制作用，C。缺陷率和C.裸纹体偏见。这些结果加强了钙素抑制作为提高抗真菌药物效率的有希望的方法的潜力。

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