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首页> 外文期刊>Journal of Clinical Microbiology >Virulence factors in Escherichia coli strains isolated from Swedish piglets with diarrhea.
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Virulence factors in Escherichia coli strains isolated from Swedish piglets with diarrhea.

机译：从瑞典仔猪与腹泻中分离的大肠杆菌菌株的毒力因子。

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Parenteral vaccination of sows against Escherichia coli diarrhea in their newborn piglets has become more common during the last decade in Sweden, and the vaccination has generally had positive effects. For more than 20 years we have investigated E. coli strains isolated from piglets and weaned pigs with enteric disorders, noting the presence of O groups, enterotoxins, and adhesins. There has been a continuous change in the frequency of these virulence factors. The present study was performed during 1983 and 1984 to follow this change, since such information is essential for the proper choice of vaccines. A total of 856 E. coli strains were obtained from 683 herds divided into three age groups: 1 to 6 days old, 1 to 6 weeks old, and weaned pigs. O group 149 still dominated in the last two age groups, while O group 101 was, for the first time, the most frequent O group in neonatal piglets. All but four O149 strains carried the K88 antigen, which was found in only one other strain (O group 8). K99 antigen was most often found in O groups 101 and 64, and among all the K99 strains ST mouse was the most common (44 of 57), followed by ST mouse-ST pig strains (12 of 57). The 987P antigen was demonstrated in 26 strains belonging to O groups 141 and OX46 and nontypable strains. Two strains belonging to O group 101 were positive for F41 antigen; one of them also carried the K99 antigen. Among all non-O149 strains, ST mouse was the most common type of enterotoxigenic E. coli ( n = 88), followed in decreasing order by ST mouse-ST pig strains ( n = 69) and ST pig strains ( n = 33). In 114 strains producing enterotoxins no adhesive factor was found. Thus, vaccination of the Swedish sow population for more than 5 years with vaccines containing O149 and K88 antigens has apparently changed the pattern of enterotoxigenic E. coli in neonatal diarrhea. The frequency of O149:K88 strains has been reduced, and O101:K99:ST mouse strains now dominate. However, O149 strains remain the dominant O group in piglets older than 1 week. In spite of all our diagnostic efforts, no virulence factors were detected in about one third of the piglets and weaned pigs with enteric disorders.
机译：在瑞典的过去十年中，在新生仔猪中对母猪对母猪的母疫苗接种患者在其新生仔猪中变得更加常见，并且疫苗接种通常具有阳性作用。 20多年来，我们研究了从仔猪和肠道疾病断奶猪中分离的大肠杆菌菌株，注意到O组，肠毒素和粘附素的存在。这些毒力因子的频率存在持续变化。 1983年和1984年期间执行本研究以跟随这种变化，因为这些信息对于疫苗的正确选择是至关重要的。总共856大肠杆菌菌株从683群分为3岁组，1至6天，1至6周龄，和断奶猪。 o组149仍然在最后两个年龄组中占主导地位，而O组101是新生儿仔猪中最常见的o组。除了四个O149菌株中均携带K88抗原，其仅在一个其他菌株（O组8）中发现。 K99抗原最常在O基团101和64中发现，并且在所有K99菌株ST小鼠中是最常见的（44 ove57），其次是ST小鼠-ST猪菌株（12个共57个）。在属于O基团141和Ox46和无卵形菌株的26个菌株中证明了987P抗原。属于O组101的两种菌株对于F41抗原呈阳性;其中一个也携带K99抗原。在所有非O149菌株中，ST小鼠是最常见的肠毒素大肠杆菌（n = 88），随后通过ST小鼠-ST猪菌株（n = 69）和st猪菌株（n = 33）降低顺序（n = 33） 。在114株中，产生肠毒素没有发现粘合剂。因此，用含有O149和K88抗原的疫苗接种瑞典母猪种群超过5年的疫苗，显然改变了新生儿腹泻的肠毒素大肠杆菌的模式。 O149：K88菌株的频率已降低，O101：K99：ST小鼠菌株现在占主导地位。然而，O149菌株仍然是1周龄仔猪中的优势O组。尽管我们的诊断努力所有，但在大约三分之一的仔猪和断奶患者中没有检测到毒力因子。

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