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首页> 外文期刊>Infection and immunity >Role of nitric oxide in host defense against an extracellular, metazoan parasite, Brugia malayi.
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Role of nitric oxide in host defense against an extracellular, metazoan parasite, Brugia malayi.

机译：一氧化氮在宿主防治中对细胞外，美唑胺寄生虫，Brugia Malayi的作用。

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The mechanisms by which mammalian hosts eliminate microparasites such as bacteria and viruses are well established. In viral infections, these mechanisms include the interferons, neutralizing and opsonizing antibodies, and cytotoxic T lymphocytes. In bacterial infections, polymorphonuclear leukocytes and macrophages, often facilitated by opsonizing antibodies, ingest the infectious agent and mediate host defense. In addition, complement, in the presence of specific antibodies directed against surface antigens, can lyse certain bacterial pathogens. In contrast, our understanding of the host defenses against metazoan, extracellular parasites is less well grounded. We obtained data by two different approaches to document the role of nitric oxide (NO) as a mediator of host defense against a human nematode parasite. First, treatment of immunocompetent, nonpermissive mice with an inhibitor of NO synthase abrogated resistance to Brugia malayi, one of the causative agents of human lymphatic filariasis. Second, treatment of permissive, immunodeficient mice with a compound that releases NO conferred resistance to infection. These data reinforce studies by James and her coworkers (I. P. Oswald, T. A. Wynn, A. Sher, and S. L. James, Comp. Biochem. Physiol. Pharmacol. Toxicol. Endocrinol. 108:11-18, 1994) on the role of NO in defense against trematode parasites and of Kanazawa et al. (T. Kanazawa, H. Asahi, H. Hata; K. Machida, N. Kagei, and M. J. Stadecker, Parasite Immunol. 15: 619-623, 1993) on cestode parasites.
机译：哺乳动物宿主消除诸如细菌和病毒等微米裂解的机制是很好的。在病毒感染中，这些机制包括干扰素，中和和调理抗体和细胞毒性T淋巴细胞。在细菌感染，多核白细胞和巨噬细胞中，经常通过Opsonizing抗体促进，摄取传染性药剂并介导宿主防御。此外，在针对表面抗原的特异性抗体存在下，补充，可以吻合某些细菌病原体。相比之下，我们对寄生寄生的理解，细胞外寄生虫接地较差。我们通过两种不同的方法获得了数据，以记录一氧化氮（NO）作为针对人类线虫寄生虫的宿主防御的介质的作用。首先，治疗免疫活性剂，非患者的抑制剂没有合成抑制剂对Brugia Malayi的抗性，人淋巴丝虫病的致病剂之一。其次，处理允许的允许的免疫缺陷小鼠，其化合物释放不赋予感染的抗性。这些数据加强了詹姆斯和她的同事（IP Oswald，Ta Wynn，A. Sher和Sl James，Comp的研究。生物学。Pharmacol。毒药醇。内分泌醇。108：11-18,1994）对否的作用防御震颤寄生虫和Kanazawa等。 （T. Kanazawa，H. Asahi，H. Hata; K. Machida，N.Kagei和M. J. Stadecker，寄生虫免疫寄生虫。15：619-623,1993）在Cestode寄生虫上。

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