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首页> 外文期刊>Infection and immunity >Lipopolysaccharide-responder and nonresponder C3H mouse strains are equally susceptible to an induced Escherichia coli urinary tract infection.
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Lipopolysaccharide-responder and nonresponder C3H mouse strains are equally susceptible to an induced Escherichia coli urinary tract infection.

机译：脂多糖响应者和非响应者C3h小鼠菌株同样易于诱导的大肠杆菌尿路感染。

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摘要

Host defense against bacterial urinary tract infections (UTI) includes both inflammatory and immune responses to infecting bacteria. The cellular events leading up to local inflammation are thought to be under genetic control and initiated by lipopolysaccharides (LPS) of gram-negative bacteria such as Escherichia coli. It has been previously reported that mice which lack functional Lps genes are more susceptible to induced E. coli UTI than mice with normal mitogenic responses to LPS. In contrast to these findings, data in this report demonstrate that LPS-responder and nonresponder C3H mouse strains are equally susceptible to E. coli UTI. When C3H/OuJ (Lps(n)/Lps(n)) and C3H/HeJ (Lps(d)/Lps(d)) were intravesically inoculated with equal numbers of uropathogenic E. coli organisms, neither strain was able to effectively resolve the induced UTI. The inability of C3H/OuJ mice to combat the infection was not due to an impaired response to LPS, nor could defect in the local inflammatory response be identified. The results indicate that factors other than LPS responsiveness are also important in determining hose resistance to UTI.
机译：对细菌尿路感染（UTI）的宿主防御包括对感染细菌的炎症和免疫反应。导致局部炎症的细胞事件被认为是在遗传控制下并由革兰氏阴性细菌（如大肠杆菌）的脂多糖（LPS）引发。之前报道，缺乏功能性LPS基因的小鼠比具有正常致命反应的小鼠更容易诱导大肠杆菌UTI对LPS的正常反应。与这些发现相比，本报告中的数据表明，LPS响应者和非响应器C3H小鼠菌株同样易于大肠杆菌UTI。当C3H / OUJ（LPS（N）/ LPS（N））和C3H / HEJ（LPS（D）/ LPS（D））以相同数量的尿羟脱发的大肠杆菌生物体接种时，任何菌株都无法有效地解决诱导的uti。 C3h / Ouj小鼠无法对抗感染的不能是由于对LPS的响应受损，也不会识别局部炎症反应的缺陷。结果表明，除了LPS响应性以外的因素在确定对UTI的软管抗性方面也很重要。

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