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首页> 外文期刊>Infection and immunity >Experimental genital mycoplasmosis: time of infection influences pregnancy outcome.
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Experimental genital mycoplasmosis: time of infection influences pregnancy outcome.

机译：实验性生殖器mycoplasmosis：感染时间影响妊娠结果。

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Genital infection of rats with Mycoplasma pulmonis causes adverse pregnancy outcome and can result in in utero spread of infection to the fetus. The current study was designed to determine whether the stage of pregnancy when infection occurs influences pregnancy outcome. Rats were inoculated with 3 X 10(7) CFU of M. pulmonis at 10 days prior to breeding (-10) or at gestational day (gd) 11 or 14 and were necropsied at gd 11, 14, or 18 or within 24 h of parturition (term). Control rats received sterile broth. M. pulmonis was isolated from the placenta, amniotic fluid, or fetal tissues only from rats infected prior to breeding (P < 0.001). All infected rats had significantly more loss of pups than did control rats (P < 0.006), but rats infected prior to breeding or at the beginning of the third trimester (gd 14) were much more likely to have fetal losses. Rats infected in the early second trimester after implantation (gd 11) did not experience severe losses. Litter sizes, total litter weight, and individual pup weight from all infected rats, regardless of gestational stage when infected, were significantly smaller than those of control rats (P < 0.001). On the basis of the results of this study, we conclude that the time of infection plays a major role in determination of pregnancy outcome and spread of infection from the genital tract to the respiratory tract.
机译：转骨囊脉冲大鼠的生殖器感染导致不良妊娠结果，导致子宫感染对胎儿的传播。目前的研究旨在判断感染发生时怀孕阶段是否会影响妊娠结局。在繁殖（-10）或在妊娠期（GD）11或14处的10天之前用3×10（7）CFU接种大鼠3×10（7）CFU，并在GD 11,14或18或24小时内进行粪便分娩（术语）。对照大鼠接受无菌肉汤。仅从育种前感染的大鼠从胎盘，羊水或胎儿组织中分离M. pulmonis（P <0.001）。所有受感染的大鼠的幼鼠损失明显多于对照大鼠（P <0.006），但在繁殖或在第三个三个月开始之前感染的大鼠更可能具有胎儿损失。在植入（GD 11）后在第二个三个月早期感染的大鼠没有经历严重的损失。无论感染时的妊娠阶段，凋落物尺寸，总凋落物重量和单个幼崽重量，明显小于对照大鼠的妊娠期（P <0.001）。在本研究的结果的基础上，我们得出的结论是，感染时间在测定妊娠结局和生殖器紊乱到呼吸道中的感染传播中发挥着重要作用。

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