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首页> 外文期刊>Applied Microbiology >A Highly Arginolytic Streptococcus Species That Potently Antagonizes Streptococcus mutans
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A Highly Arginolytic Streptococcus Species That Potently Antagonizes Streptococcus mutans

机译：一种高度精神溶解的链球菌物种，其纯粹拮抗链球菌

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The ability of certain oral biofilm bacteria to moderate pH through arginine metabolism by the arginine deiminase system (ADS) is a deterrent to the development of dental caries. Here, we characterize a novel Streptococcus strain, designated strain A12, isolated from supragingival dental plaque of a caries-free individual. A12 not only expressed the ADS pathway at high levels under a variety of conditions but also effectively inhibited growth and two intercellular signaling pathways of the dental caries pathogen Streptococcus mutans . A12 produced copious amounts of H_(2)O_(2) via the pyruvate oxidase enzyme that were sufficient to arrest the growth of S. mutans . A12 also produced a protease similar to challisin (Sgc) of Streptococcus gordonii that was able to block the competence-stimulating peptide (CSP)–ComDE signaling system, which is essential for bacteriocin production by S. mutans . Wild-type A12, but not an sgc mutant derivative, could protect the sensitive indicator strain Streptococcus sanguinis SK150 from killing by the bacteriocins of S. mutans . A12, but not S. gordonii , could also block the XIP ( comX -inducing peptide) signaling pathway, which is the proximal regulator of genetic competence in S. mutans , but Sgc was not required for this activity. The complete genome sequence of A12 was determined, and phylogenomic analyses compared A12 to streptococcal reference genomes. A12 was most similar to Streptococcus australis and Streptococcus parasanguinis but sufficiently different that it may represent a new species. A12-like organisms may play crucial roles in the promotion of stable, health-associated oral biofilm communities by moderating plaque pH and interfering with the growth and virulence of caries pathogens.
机译：某些口腔生物膜细菌通过精氨酸脱氨酶系统（ADS）通过精氨酸代谢中温和pH的能力是一种威慑力的龋齿。在这里，我们表征了一种新型链球菌菌株，指定的菌株A12，与无龋齿的Suprictival牙菌斑块分离。 A12不仅在多种条件下表达了高水平的广告途径，而且有效地抑制了龋齿病原体链球菌的生长和两种细胞间信号通路。 A12通过丙酮酸氧化酶产生大量的H_（2）O_（2），足以阻止S. mutans的生长。 A12还产生了类似于链球菌的核酸细胞（SGC）的蛋白酶，其能够阻断刺激刺激的肽（CSP） - Comde信号传导系统，这对于S. mutans的细菌素产生至关重要。野生型A12，但不是SGC突变衍生物，可以保护敏感指标菌株SK150由S.Ultans的细菌杂菌杀死。 A12，但不是S.Gordonii，也可以阻断XIP（Comx-induct Peptide）信号通路，这是S.Ulantans遗传竞争力的近端调节器，但该活动不需要SGC。确定A12的完整基因组序列，和系统托儿科分析与链球菌参考基因组比较A12。 A12与链球菌和链球菌副链球菌和链球菌寄生虫寄生虫最常见，但它可能代表新物种。 A12样的生物可能在通过调节斑块pH和干扰龋病病原体的生长和毒力来发挥稳定的健康相关的口服生物膜社区的关键作用。

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