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首页> 外文期刊>Infection and immunity >CD4+ T Cells but Not CD8+ or γδ+ Lymphocytes Are Required for Host Protection against Mycobacterium avium Infection and Dissemination through the Intestinal Route
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CD4+ T Cells but Not CD8+ or γδ+ Lymphocytes Are Required for Host Protection against Mycobacterium avium Infection and Dissemination through the Intestinal Route

机译：CD4 + T细胞但不需要CD8 +或γδ+淋巴细胞，以防止分枝杆菌感染和通过肠道途径传播

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Disseminated Mycobacterium avium infection is common in AIDS patients that do not receive anti-AIDS therapy and in patients for whom therapy fails. M. avium is commonly acquired by ingestion, and a large number of AIDS patients have M. avium in their intestinal tracts. To better understand the dynamics of the infection in patients with AIDS, we studied orally infected mice. To determine if immunocompetent mice challenged orally with M. avium can develop protection against the infection, and if so, which cell population(s) is responsible for the protection, we exposed wild-type as well as CD4?/?, CD8?/?, and γδ?/? knockout mice to low concentrations of M. avium strain 101 given orally, followed by treatment with azithromycin. After 1 month, the mice were challenged with kanamycin-resistant M. avium 104. Only CD4+ T cells appeared to be required for protection against the second challenge. Both CD4+ and CD8+ T cells produced comparable amounts of gamma interferon after the first exposure to the bacterium. Tumor necrosis factor alpha was elevated in CD4+ T cells but not in CD8+ T cells. Following exposure to a small inoculum of mycobacteria orally, wild-type mice did not develop disseminated infection for approximately 4 months, although viable bacteria could be observed in the mesenteric lymph nodes. The ingestion of small numbers of M. avium cells induces a protective immune response in the intestines against subsequent infection. However, the bacteria remain viable in intestinal lymph nodes and might disseminate later.
机译：传播分枝杆菌和evium 感染是艾滋病患者常见的，这些艾滋病患者不接受助剂治疗和治疗失败的患者。 m。 Avium 通常是通过摄取而获得的，大量艾滋病患者有 M。在他们的肠道中饲养途中。为了更好地了解艾滋病患者感染的动态，我们研究了口服感染的小鼠。确定免疫活性小鼠是否与 M口头挑战。 Avium 可以对感染进行保护，如果是，哪种细胞群体负责保护，我们暴露了野生型以及CD4 ，CD8 ，CD8 < sup>？/α/α/α/ sup>，和γδα/ηs≤k/ sup>敲除小鼠以低浓度的 m。口服给出的途径菌株101，然后用氮霉素治疗。 1个月后，小鼠用卡那霉素抗性 m攻击。 Avium 104.只有CD4 + T细胞似乎需要防止第二个挑战。 CD4 + 和CD8 + T细胞在第一次暴露于细菌后产生了可比量的γ干扰素。肿瘤坏死因子α在CD4 + t细胞中升高，但不在CD8 + t细胞中。暴露于口服的分枝杆菌的小型接种后，野生型小鼠在肠系膜淋巴结中可以观察到可行的细菌，但野生型小鼠并未发展出现逾期4个月。摄入少量 m。 Avium 细胞在肠中诱导免受随后的感染的保护性免疫应答。然而，细菌在肠淋巴结中仍然可行，并且可能稍后传播。

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