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首页> 外文期刊>Infection and immunity >Diminished Monocyte Function in Microfilaremic Patients with Lymphatic Filariasis and Its Relationship to Altered Lymphoproliferative Responses
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Diminished Monocyte Function in Microfilaremic Patients with Lymphatic Filariasis and Its Relationship to Altered Lymphoproliferative Responses

机译：微诊断淋巴丝体患者中的单核细胞功能减少及其与改变淋巴抑制性反应的关系

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Antigen-specific hyporesponsiveness to filarial antigens is a phenomenon observed in patent infection with lymph-dwelling filarial parasites of humans. This phenomenon has been attributed to a multitude of factors, one of which is altered monocyte function. To examine the role played by monocytes in filarial infection, we assessed the responses of monocytes obtained from normal and filarial parasite-infected individuals to both crude filarial antigen and purified recombinant filarial antigen WbSXP-1 and attempted to relate these to the altered lymphoproliferative responses seen in filarial infection. Monocytes from microfilaremic (MF) patients demonstrated an inability to respond to lipopolysaccharide compared to monocytes from endemic normal persons or from lymphedema patients. Indeed, interleukin 1β (IL-1β) production was severely limited, a finding that did not extend to monocyte responses to filarial antigens. Serum from MF patients reduced adherence and spreading of normal monocytes, a finding not seen with serum from the other clinical groups. Interestingly, there was a significant correlation between the production of IL-1β and adherence. Moreover, the levels of spontaneous production of IL-1β correlated with high levels of spontaneous secretion of IL-10. The effects observed were not a result of diminished viability or alteration in the expression of the cell surface markers CD14 and HLA-DR. These data suggest that monocyte function is dampened in MF patients, a finding which could alter lymphoproliferative responses during patent infection.
机译：对纤维抗原的抗原特异性低反向是在具有人类淋巴结的丝丝寄生虫的专利感染中观察到的现象。这种现象归因于多种因素，其中一个是单核细胞功能改变的。为了检查单核细胞中单核细胞的作用，我们评估了从正常和丝状寄生虫感染的个体获得的单核细胞的反应，以粗糙的叶粒抗原和纯化的重组丝状抗原WBSXP-1并试图将这些与所见的改变的淋巴抑制性反应相关联在丝丝感染。来自微诊断（MF）患者的单核细胞表明，与人群正常人或淋巴米患者的单核细胞相比，无法对脂多糖进行反应。实际上，白细胞介素1β（IL-1β）生产严重限制，发现不延伸到单核细胞对丝状抗原的反应。来自MF患者的血清降低了正常单核细胞的粘附和传播，从其他临床组中没有看到血清的发现。有趣的是，IL-1β和依从性之间存在显着相关性。此外，IL-1β的自发产生水平与IL-10的高水平自发性分泌相关。所观察到的效果不是在细胞表面标记CD14和HLA-DR的表达中减少的活力或改变的结果。这些数据表明，单核细胞功能在MF患者中抑制了一种，该发现可以在专利感染期间改变淋巴抑制性反应。

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