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Inactivated Influenza Vaccine Efficacy: Diminished Antigenicity of Split-Product Vaccines in Mice

机译：灭活流感疫苗疗效：小鼠中分裂产物疫苗的抗原性降低

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Groups of 60 to 120 mice were given a single intraperitoneal inoculation of varying dilutions of commercially prepared and licensed bivalent (A/England and B/Mass) and monovalent (A/Aichi or B/Hong Kong) inactivated influenza vaccines, and their antibody responses at 14 days were quantitated by hemagglutination inhibition tests. Split-product vaccines prepared by the treatment of A/England, B/Mass, and B/Hong Kong whole virus with Tween-80 and either tributylphosphate or ether produced significantly lower mean antibody titers than did equivalent whole-virus preparations. The rates of seroconversion (<1:8 to ≥1:8) at the various dilutions tested were also significantly reduced when these split-product vaccines were given. When the antigen content of all vaccines was quantitated by the chick cell agglutination test, between 10 and 100 times more split-product antigen than whole-virus antigen was required to produce seroconversion in 50% of the mice tested. Differences between split-product and whole-virus A/Aichi vaccines were less marked. These data point out the need to consider factors other than hemagglutinin content alone in determining the immunogenicity of inactivated influenza vaccines.
机译：给予60至120只小鼠的单一腹膜内接种，不同稀释的商业制备和许可的二价（A / England和B / Mass）和单价（A / AICHI或B / HONK）灭活的流感疫苗，及其抗体反应通过血细胞凝集抑制试验定量14天。通过治疗A / England，B / Mass和B /香港全部病毒制备的分体疫苗，Tween-80和甲基磷酸酯或乙醚产生明显低于等同的全病毒制剂的平均抗体滴度。当给出这些分裂产物疫苗时，测试的各种稀释液的血清转化（<1：8至≥1：8）的速率也显着降低。当所有疫苗的抗原含量通过小鸡细胞凝集试验定量时，需要比全病毒抗原在10至100倍之间，所以需要在测试的50％的小鼠中产生血清转化。分裂产品和全病毒A / AICHI疫苗之间的差异较小。这些数据指出，需要考虑除血凝素含量之外的因素，在确定灭活的流感疫苗的免疫原性时。

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