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首页> 外文期刊>Bulletin of the American Physical Society >APS -84th Annual Meeting of the APS Southeastern Section - Event - Mid-IR Spectroscopy of Dried Serum Samples: An Application for Colitis Prescreening
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APS -84th Annual Meeting of the APS Southeastern Section - Event - Mid-IR Spectroscopy of Dried Serum Samples: An Application for Colitis Prescreening

机译：APS -84STH APS东南部的年会 - 事件 - 干燥血清样品的中红外光谱：结肠炎预筛选的应用

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At present, colonoscopy/ileoscopy and small bowel follow through are considered as gold standard for IBD tests. Despite their unequivocal benefit for the IBD tests, compliance rates of eligible population for prescreening is very small due to discomfort, expense, and risk of complications. Developing a minimally invasive and cost-effective prescreen strategy is thus critical. We present ATR-FTIR spectroscopy of serum with appropriate data handling frameworks can be used for reliably screen experimental colitis. The study on experimental colitis models: interleukin 10 knockout mouse, and dextran sodium sulfate-induced of colitis mouse while employing collagen-induced arthritis models, TLR-5 knockout models of metabolic diseases as control, emphasizes the diagnostic potential of this technique for the prescreening. Absorbance values of the different spectral bands, hierarchical clustering and integral values of the component bands by curve fitting, show significant differences (p-value extless 0.05) between spectra representing control and colitis mice. The preliminary result hints us the potential application of technique while diagnosing ulcerative colitis and Crohn's Disease and to monitor during treatment.
机译：目前，结肠镜检查/对齐和小肠润肺被认为是IBD测试的金标准。尽管对IBD测试的缺乏良好益处，但由于不适，费用和并发症的风险，符合条件的预筛选人口的符合性率非常小。因此，开发微创和成本效益的预训练策略是至关重要的。我们呈现血清ATR-FTIR光谱，具有适当的数据处理框架可用于可靠筛选实验性结肠炎。实验性结肠炎模型的研究：白细胞介素10敲除小鼠，葡萄球菌诱导的结肠炎小鼠，同时采用胶原诱导的关节炎模型，TLR-5作为控制的代谢疾病淘汰模型，强调了这种技术的诊断潜力。通过曲线拟合的不同光谱带，分层聚类和组分带的积分值的吸光度值，显示出代表控制和结肠炎小鼠的谱之间的显着差异（P值下方0.05）。初步结果暗示了我们在诊断溃疡性结肠炎和克罗恩病和治疗期间监测的潜在应用。

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