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Systems-Pharmacology Dissection of Traditional Chinese Medicine Compound Saffron Formula Reveals Multi-scale Treatment Strategy for Cardiovascular Diseases

机译：系统 - 药理学解剖中药复合藏红花公式揭示了心血管疾病的多尺度治疗策略

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Cardiovascular diseases (CVDs) have been regarding as “the world’s first killer” of human beings in recent years owing to the striking morbidity and mortality, the involved molecular mechanisms are extremely complex and remain unclear. Traditional Chinese medicine (TCM) adheres to the aim of combating complex diseases from an integrative and holistic point of view, which has shown effectiveness in CVDs therapy. However, system-level understanding of such a mechanism of multi-scale treatment strategy for CVDs is still difficult. Here, we developed a system pharmacology approach with the purpose of revealing the underlying molecular mechanisms exemplified by a famous compound saffron formula (CSF) in treating CVDs. First, by systems ADME analysis combined with drug targeting process, 103 potential active components and their corresponding 219 direct targets were retrieved and some key interactions were further experimentally validated. Based on this, the network relationships among active components, targets and diseases were further built to uncover the pharmacological actions of the drug. Finally, a “CVDs pathway” consisted of several regulatory modules was incorporated to dissect the therapeutic effects of CSF in different pathological features-relevant biological processes. All this demonstrates CSF has multi-scale curative activity in regulating CVD-related biological processes, which provides a new potential way for modern medicine in the treatment of complex diseases.
机译：由于发病率和死亡率引起的近年来，心血管疾病（CVDS）一直是人类的“世界上第一个杀手”，所涉及的分子机制非常复杂，仍然不清楚。中医（TCM）涉及从综合和整体角度进行复杂疾病的目的，这在CVDS治疗中表现出有效性。然而，系统级别了解CVDS的多规模治疗策略机制仍然困难。这里，我们开发了一种系统药理学方法，目的是揭示在治疗CVDS中的着名化合物杯式（CSF）所例示的潜在的分子机制。首先，通过系统ADME分析与药物靶向过程结合，检索103个潜在的活性组分及其相应的219个直接靶标，并进一步实验验证了一些关键相互作用。基于此，进一步建立了活性成分，靶向和疾病之间的网络关系以发现药物的药理作用。最后，掺入了由几种调节模块组成的“CVDS途径”，以将CSF的治疗效果描述在不同的病理学特征相关的生物过程中。所有这些都证明了CSF在调节CVD相关的生物过程中具有多种疗效活动，这为现代医学提供了一种新的潜在方式，治疗复杂疾病。

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