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首页> 外文期刊>Scientific reports. >Modelling intracellular competition for calcium: kinetic and thermodynamic control of different molecular modes of signal decoding
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Modelling intracellular competition for calcium: kinetic and thermodynamic control of different molecular modes of signal decoding

机译：钙的细胞内竞争模拟：信号解码不同分子模式的动力学和热力学控制

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Frequently, a common chemical entity triggers opposite cellular processes, which implies that the components of signalling networks must detect signals not only through their chemical natures, but also through their dynamic properties. To gain insights on the mechanisms of discrimination of the dynamic properties of cellular signals, we developed a computational stochastic model and investigated how three calcium ion (Ca(2+))-dependent enzymes (adenylyl cyclase (AC), phosphodiesterase 1 (PDE1), and calcineurin (CaN)) differentially detect Ca(2+) transients in a hippocampal dendritic spine. The balance among AC, PDE1 and CaN might determine the occurrence of opposite Ca(2+)-induced forms of synaptic plasticity, long-term potentiation (LTP) and long-term depression (LTD). CaN is essential for LTD. AC and PDE1 regulate, indirectly, protein kinase A, which counteracts CaN during LTP. Stimulations of AC, PDE1 and CaN with artificial and physiological Ca(2+) signals demonstrated that AC and CaN have Ca(2+) requirements modulated dynamically by different properties of the signals used to stimulate them, because their interactions with Ca(2+) often occur under kinetic control. Contrarily, PDE1 responds to the immediate amplitude of different Ca(2+) transients and usually with the same Ca(2+) requirements observed under steady state. Therefore, AC, PDE1 and CaN decode different dynamic properties of Ca(2+) signals.
机译：通常，常见的化学实体触发相反的蜂窝过程，这意味着信令网络的组件必须通过其化学性质来检测信号，而且还通过其动态性质来检测信号。为了了解对细胞信号动态性质的鉴别机制，我们开发了一种计算随机模型，并研究了三种钙离子（Ca（2 +））依赖性酶（腺苷环酶（AC），磷酸二酯酶1（PDE1）和钙蛋白（CAN））差异地检测海马树突脊柱中的CA（2+）瞬变。 AC，PDE1的平衡可以决定对相对于Ca（2 +）诱导的突触塑性，长期增强（LTP）和长期凹陷（LTD）的发生。可以对LTD是必不可少的。 AC和PDE1间接调节，间接蛋白激酶A，其在LTP期间抵消罐。 AC，PDE1和可以用人工和生理CA（2+）信号的刺激表明，AC和可通过用于刺激它们的信号的不同性质动态调节Ca（2+）要求，因为它们与Ca的相互作用（2+ ）经常发生在动力学控制下。相反，PDE1响应不同CA（2+）瞬变的直接幅度，并且通常在稳态下观察到相同的CA（2+）要求。因此，AC，PDE1和可以解码CA（2+）信号的不同动态特性。

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