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首页> 外文期刊>Scientific reports. >Diagnostic accuracy of liver stiffness measurement in chronic hepatitis B patients with normal or mildly elevated alanine transaminase levels
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Diagnostic accuracy of liver stiffness measurement in chronic hepatitis B patients with normal or mildly elevated alanine transaminase levels

机译：慢性乙型肝炎患者肝硬化测量肝硬化患者诊断准确性，丙氨酸转氨酶水平

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We aimed to evaluate the diagnostic accuracy of liver stiffness measurement (LSM) in 188 chronic hepatitis B (CHB) patients with alanine transaminase (ALT) ≤ twice the upper limit of normal (ULN). Liver fibrosis was staged using METAVIR scoring system. Define significant fibrosis as F2-F4, severe fibrosis as F3-F4, and cirrhosis as F4. To predict F2-F4, the AUROC of LSM was higher than that of APRI (0.86 vs 0.73, p?=?0.001) and FIB-4 (0.86 vs 0.61, p??0.001). To predict F4, the AUROC of LSM was also higher than that of APRI (0.93 vs 0.77, p?=?0.012) and FIB-4 (0.93 vs 0.64, p??0.001). Patients with ALT levels 1–2 ULN had higher cut-off values than patients with normal ALT levels for the diagnosis of F2-F4 (6.5 vs 6 kPa) and F4 (10.2 vs 7.8 kPa). Using cut-off values regardless of ALT levels, the diagnostic accuracy of LSM was 81% for F2-F4, and 89% for F4. Applying ALT-stratified cut-off values, the diagnostic accuracy of LSM was 82% for F2-F4, and 86% for F4. In conclusion, LSM is a reliable noninvasive test for the diagnosis of liver fibrosis. Applying ALT-stratified cut-off values did not enhance diagnostic accuracy of LSM in CHB patients with ALT ≤ 2 ULN.
机译：我们旨在评估188例慢性乙型肝炎（CHB）丙氨酸转氨酶（ALT）≤20℃的肝硬化测量（LSM）的诊断准确性（ALT）≤正常上限（ULN）的两倍。使用Metavir评分系统分阶段阶段进行肝纤维化。将显着的纤维化定义为F2-F4，剧烈纤维化作为F3-F4，以及肝硬化作为F4。为了预测F2-F4，LSM的菌射高于APRI（0.86 Vs 0.73，P≤0.001）和FIB-4（0.86 Vs 0.61，P≤0.001）。为了预测F4，LSM的菌射也高于APRI（0.93 Vs 0.77，P≤0.012）和FIB-4（0.93 Vs 0.64，P≤0.001）。 ALT水平1-2 uln的患者具有比具有正常ALT水平的患者更高的截止值，用于诊断F2-F4（6.5 Vs 6 KPA）和F4（10.2 Vs 7.8 KPA）。使用截止值无论ALT级别如何，LSM的诊断精度为F2-F4为81％，F4为89％。应用Alt-stratified截止值，LSM的诊断精度为F2-F4的82％，F4为86％。总之，LSM是一种可靠的非侵入性试验，用于诊断肝纤维化。应用Alt-stratified截止值并未增强CHB患者的LSM诊断准确性Alt≤2uln。

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