...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>BDJ open. >Molecular markers relevant to myocardial injury following dental extraction in patients with or without coronary artery disease
【24h】

Molecular markers relevant to myocardial injury following dental extraction in patients with or without coronary artery disease

机译：与冠状动脉疾病或没有冠状动脉疾病的患者牙科提取后与心肌损伤相关的分子标记

获取原文
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The aim of this study was to characterize biological changes following dental extractions in patients with or without coronary artery disease (CAD). Forty-five patients (36 males and 9 females) referred for dental extraction underwent treatment and provided blood samples before, immediately after, and 24?h after the procedure. A broad array of biomarkers was employed to assess myocardial injury (highly sensitive troponin T, hs-TnT), bacterial burden (LPS endotoxin activity), and systemic inflammation (CRP, fibrinogen, IFN-γ, IL-1β, IL-6, IL-8, IL-10, IL-12, and TNF-α). Dental extraction in patients with or without CAD was associated with rises in hs-TnT (p?=?0.013), hs-CRP (p??0.001), fibrinogen (p?=?0.005), endotoxin activity (p??0.001), IFN-γ (p??0.001), IL-6 (p??0.001), IL-8 (p?=?0.011), and IL-12 (p??0.001) at 24?h compared with immediately post procedure. Changes in systemic inflammation and endotoxin activity were more evident in those with hs-TnT rise. Simple dental extractions may cause mild increase in hs-TnT, indicating minor myocardial injury in both patients with or without CAD. Acute systemic inflammation and endotoxemia could represent a possible link between invasive dental treatment and increased risk of acute cardiovascular events. These findings indicate that invasive dental treatment (as simple as a single dental extraction) may impact negatively on clinical outcomes in dental patients, especially those with CAD.
机译：本研究的目的是在患有冠状动脉疾病（CAD）的患者牙科提取后的生物学变化表征。第四十五名患者（36名男性和9名女性）提到牙科萃取接受治疗，并在手术后立即提供血液样品和24μm。使用广泛的生物标志物来评估心肌损伤（高度敏感的肌钙蛋白T，HS-TNT），细菌负担（LPS内毒素活性）和全身炎症（CRP，纤维蛋白原，IFN-γ，IL-1β，IL-6， IL-8，IL-10，IL-12和TNF-α）。有或没有CAD患者的牙科提取与HS-TNT的升高有关（P？= 0.013），HS-CRP（P？<0.001），纤维蛋白原（P？= 0.005），内毒素活性（P？< ？0.001），IFN-γ（p≤0.001），IL-6（p≤0.001），IL-8（p？= 0.011），24个（p？<= 0.001） ？H与立即发布程序相比。在HS-TNT上升的那些中，全身炎症和内毒素活性的变化更明显。简单的牙科提取可能导致HS-TNT的轻度增加，表明两种患者或没有CAD的患者的轻微心肌损伤。急性全身炎症和内毒素血症可以代表侵袭性牙科治疗和急性心血管事件的风险增加之间可能的联系。这些发现表明，侵入性牙科治疗（如单一牙科提取）可能会对牙科患者的临床结果产生负面影响，尤其是带CAD的临床结果。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号