• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>BMC Ophthalmology >Highly suspected primary intraocular lymphoma in a patient with rheumatoid arthritis treated with etanercept: a case report
【24h】

Highly suspected primary intraocular lymphoma in a patient with rheumatoid arthritis treated with etanercept: a case report

机译：高度疑似初级眼内淋巴瘤，患有类风湿性关节炎的患者用entanercept治疗：案例报告

获取原文
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

To describe a case of highly suspected primary intraocular lymphoma (PIOL) in a patient using etanercept for the treatment of rheumatoid arthritis. A 50-year-old female patient presented with decreased vision in her left eye that lasted for a week. She had a 15-year history of seropositive rheumatoid arthritis (RA), and had been taking weekly etanercept for the preceding 8 months. Funduscopic examination and SD-OCT showed a swollen ellipsoid zone (EZ) and a retinal pigment epithelium (RPE) irregularity of the right eye. We also noted EZ disruption and a RPE irregularity in the left eye. As subretinal infiltration was aggravated in the right eye after the initial treatment, we completed a vitrectomy. Vitreous cytology revealed PIOL with positive CD20 immunostaining. She was treated with serial intravitreal methotrexate injections and systemic chemotherapy. After the treatment, subretinal infiltration and subRPE deposits were decreased in the right eye with no evidence of recurrence in either eye. This case suggests a potential relationship between immunosuppression with anti-TNFα medication, and increased risk for lymphoma, especially in patients with underlying rheumatologic disorders and especially in patients with suspected chronic refractory uveitis.
机译：描述使用Etannept用于治疗类风湿性关节炎的患者中高度疑似初级眼内淋巴瘤（PIOL）的情况。一名50岁的女病人在她的左眼持续下降了一周。她有15年的血清阳性类风湿性关节炎（RA）历史，并为前8个月进行了每周依赖伊西普。眼底检查和SD-OCT显示出溶胀的椭圆形区（EZ）和视网膜颜料上皮（RPE）不规则的右眼。我们还注意到左眼中的ez中断和rpe不规则性。由于在初始治疗后右眼加剧了尺寸渗透，我们完成了一种玻璃体切除术。玻璃体细胞学揭示了具有阳性CD20免疫染色的PIOL。她被连续嗜型甲氨蝶呤注射和全身化疗治疗。在治疗后，右眼减少了次震级浸润和亚磷酸沉积物，没有任何眼睛复发的证据。这种情况表明，免疫抑制与抗TNFα药物之间的潜在关系，以及淋巴瘤的风险增加，尤其是患有潜在风湿病患者的患者，特别是涉嫌慢性耐火葡萄炎患者。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号