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Comparison of different settings for yellow subthreshold laser treatment in diabetic macular edema

机译：糖尿病黄斑水肿中黄色亚阈值激光治疗不同设置的比较

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To assess the safety and efficacy of two subthreshold parameters (5 and 15% duty cycle (DC)) compared to standard ETDRS (early treatment of diabetic retinopathy study) continuous wave (CW) laser. In this prospective randomized study, 30 eyes from 20 patients with non-center involving macular edema were randomized into 3 different groups: 5% DC, 15% DC and CW navigated modified ETDRS laser treatment. Titration in subthreshold groups was performed with 30% of the threshold power, decided with microsecond pulses. CW laser was titrated to a barely visible burn. All patients underwent microperimetry, thickness measurements and visual acuity examinations at baseline, 6?weeks and 12?weeks post treatment. At three months follow up, retinal sensitivity was significantly reduced in the CW group by -?2.2?dB whereas in both subthreshold groups, retinal sensitivity increased by 2.4?dB for 5% and 1.9?dB for 15% DC with no significant difference. Retinal volume (mm3) decreased in both subthreshold groups by 0.08?±?0.3 and 0.12?±?0.11 in 5 and 15% DC group respectively. Whereas the CW group showed volume increase of 0.55?±?0.92 (p?=?0.02 and 0.01 for 5 and 15% DC groups). Visual acuity remained stable in all 3 groups (-?0.7 letter in 5% DC; 2.11 letters in 15% DC and 0.88 in CW with no significant difference). Subthreshold microsecond laser was shown to be safe and effective with both 5 and 15% DC as compared to conventional photocoagulation with ETDRS parameters. The 15% DC setting trended to achieve better anatomical, visual and functional outcomes. Retrospectively registered ( NCT03571659 , 06/26/2018).
机译：与标准ETDRS（糖尿病视网膜病变研究的早期处理）连续波（CW）激光相比，评估两个亚阈值参数（5和15％占空比（DC））的安全性和有效性。在这项前瞻性随机研究中，从20名涉及黄斑水肿的非中心患者的30只眼睛随机分为3种不同的组：5％DC，15％DC和CW导航改性的ETDRS激光治疗。以30％的阈值进行阈值组在亚阈值组中滴定，用微秒脉冲确定。 CW激光滴定到几乎可见的烧伤中。所有患者在基线接受微型测量，厚度测量和视力检查，6？周和12个月，治疗后周数。在三个月后，CW组的视网膜敏感性显着降低 - Δ2.2？DB，而在亚阈值组中，视网膜敏感性增加2.4℃，5％和1.9？DB，15％DC没有显着差异。视网膜体积（MM3）在两个亚阈值基团中降低0.08°±0.3和0.12？±0.11，分别为5％和15％DC组。而CW组显示体积增加0.55？±0.92（P？= 0.02和0.01，5％和15％DC组）。视力在所有3组中保持稳定（ - ？0.7个字母5％DC; 2.11在15％DC中的字母和0.88的CW，无显着差异）。与用ETDRS参数的常规光凝相比，亚阈值微秒激光显示为5和15％DC安全且有效。 15％的DC设定趋势趋势达到更好的解剖，视觉和功能结果。回顾性注册（NCT03571659,06 / 26/2018）。

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