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首页> 外文期刊>BMC Ophthalmology >Behavior of hyperreflective foci in non-infectious uveitic macular edema, a 12-month follow-up prospective study
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Behavior of hyperreflective foci in non-infectious uveitic macular edema, a 12-month follow-up prospective study

机译：非传染性Uveical Maruitom Matema在非传染性UVEITIC MATEMA中的行为，一个12个月的随访前瞻性研究

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Hyperreflective foci have been described in OCT imaging of patients with retinal vascular diseases. It has been suggested that they may play a role as a prognostic factor of visual outcomes in these diseases. The purpose of this study is to describe the presence of hyperreflective foci in patients with non-infectious uveitic macular edema and evaluate their behavior after treatment. We conducted a multicenter, prospective, observational, 12-month follow-up study. Inclusion criteria were age??18?years and a diagnosis of non-infectious uveitic macular edema, defined as central macular thickness of ?300?μm as measured by OCT and fluid in the macula. Collected data included best corrected visual acuity, central macular thickness and the presence, number and distribution (inner or outer retinal layers) of hyperreflective foci. Evaluations were performed at baseline, and at 1, 3, 6, and 12?months after starting treatment. We included 24 eyes of 24 patients. The frequency of patients with ≥11 hyperreflective foci was 58.4% at baseline, falling to 20.8% at 12?months. Further, hyperreflective foci were observed in the outer retinal layers in 50% of patients at baseline and just 28.6% at 12?months. Mean LogMAR visual acuity improved from 0.55 (95% CI 0.4-0.71) at baseline to 0.22 (95% CI 0.08-0.35) at 12?months (p??0.001). Mean central macular thickness decreased from 453.83?μm (95% CI 396.6-511) at baseline to 269.32?μm (95% CI 227.7-310.9) at 12?months (P??0.001). Central macular thickness was associated with number (p?=?0.017) and distribution (p?=?0.004) of hyperreflective foci. We have observed hyperreflective foci in most of our patients with non-infectious uveitic macular edema. During follow-up and after treatment, the number of foci diminished and they tended to be located in the inner layers of the retina.
机译：已经在高温血管疾病患者的OCT成像中描述了过脱硫灶。有人建议，他们可能在这些疾病中的视觉结果的预后因素发挥作用。本研究的目的是描述非传染性葡萄质黄斑水肿患者的过度选择性病灶的存在，并在治疗后评估其行为。我们进行了多中心，前瞻性，观测，12个月的后续研究。纳入标准年龄是年龄？> 18岁，诊断非传染性葡萄质黄斑水肿，被定义为Mucula和黄斑中的液体测量的中央黄斑厚度>？300≤μm。收集的数据包括超腐蚀性焦点的最佳校正的视力，中央黄斑厚度和存在，数量和分布（内或外视网膜层）。评估在基线进行，在开始治疗后1,3,6和12个月内进行。我们包括24名患者的24只眼睛。基线≥11个过度反射灶患者的频率为58.4％，12.8％下降至12.8％。此外，在基线50％的患者中，在外视网膜层中观察到过脱铁焦点，在12.6％的时间内仅为28.6％。平均Logmar视力在12.55（95％CI 0.4-0.71）下改善为0.22（95％CI 0.08-0.35），在12？个月（p？<0.001）。平均中央黄斑厚度从453.83Ω·μm（95％CI 396.6-511）下降到12.个月（P？<0.001）。中央黄斑厚度与数量（p？= 0.017）和分布（p？= 0.004）的超侵略性焦点相关。我们在我们的大多数患者中观察到过度反射性焦点，我们的大多数患有非传染性UVEITCEM MATICAL水肿。在后续行动和治疗期间，焦点的数量减少，它们倾向于位于视网膜的内层中。

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