• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>BMC Ophthalmology >Human Herpesvirus-6 corneal Endotheliitis after intravitreal injection of Ranibizumab
【24h】

Human Herpesvirus-6 corneal Endotheliitis after intravitreal injection of Ranibizumab

机译：人类疱疹病毒-6术治疗Ranibizumab后的角膜内皮炎

获取原文
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

To report the first case of human herpesvirus-6 (HHV-6) corneal endotheliitis that developed after intravitreal ranibizumab injections. A 63-year-old man with a medical history of diabetes and systemic steroid treatment for bullous pemphigoid had been receiving intravitreal injections of ranibizumab in the left eye for 2 years according to a Pro Re Nata treatment regimen for macular edema associated with branch retinal vein occlusion. Twenty days after the last injection, the patient presented with pain and decreased visual acuity in his left eye. His best corrected visual acuity in the left eye was 2/200, and intraocular pressure was 45 mmHg with edema of the central stromal cornea, mild conjunctival injection, intermediate keratic precipitates, and mild anterior chamber reaction. HHV-6 DNA was detected in the aqueous humor using multiplex strip polymerase chain reaction, and it was identified as variant A, HHV-6A. A diagnosis of HHV-6A-associated corneal endotheliitis was made. Oral valganciclovir and topical ganciclovir therapy was initiated with good resolution of all symptoms and signs. HHV-6A can be a possible complication of intravitreal ranibizumab therapy. To the best of our knowledge, this is the first reported case of HHV-6A corneal endotheliitis following intravitreal ranibizumab injection.
机译：报告术后人类疱疹病毒-6（HHV-6）角膜内皮炎的第一种案例，在玻璃体杆菌植物中注射后开发。一名63岁的男子患有糖尿病和全身类固醇治疗的病史，大疱性Pemphigoid患者在左眼术治疗术中的Ranibizumab术治疗2年，根据Pro Re Nata治疗方案，用于与分支视网膜静脉相关的黄斑水肿闭塞。在最后一次注射后二十天，患者患有疼痛并在左眼中减少视力。他在左眼的最佳矫正视力是2/200，眼压为45mmHg，中央基角膜的水肿，轻度结膜注射，中间腔沉淀物和轻度前室反应。使用多重带状聚合酶链反应在水幽默中检测HHV-6 DNA，并将其鉴定为变体A，HHV-6a。制造了HHV-6a相关的角膜内皮炎的诊断。口服valganciclovir和局部甘道罗韦治疗是良好的解决所有症状和标志的疗法。 HHV-6A可以是玻璃体内Ranibizumab疗法的可能并发症。据我们所知，这是第一个报告的HHV-6A角膜内皮炎术后RANIBIZUMAB注射液。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号