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首页> 外文期刊>BMC Gastroenterology >Complications of enterostomy and related risk factor analysis of very early onset inflammatory bowel disease with interleukin-10 signalling deficiency: a single-centre retrospective analysis
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Complications of enterostomy and related risk factor analysis of very early onset inflammatory bowel disease with interleukin-10 signalling deficiency: a single-centre retrospective analysis

机译：白细胞介素-10信号缺乏对肠胃术和相关危险因子分析的并发症及其早期发病性炎症性疾病：单中心回顾性分析

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Interleukin-10 (IL10) signalling pathway deficiency results in severe very early onset inflammatory bowel disease (VEOIBD), and enterostomy is often inevitable. However, studies in these surgical populations are lacking. This study aims to determine the enterostomy characteristics, postoperative complications and related risk factors in enterostomy patients. From March 1, 2015, to December 31, 2018, patients with IL10R-mutation who underwent enterostomy were recruited for analysis. We collected data on the patients’ clinical characteristics, enterostomy characteristics, postoperative complications and related risk factors. Twelve patients required emergency enterostomy, and 10 patients underwent elective enterostomy. Twelve patients experienced postoperative complications, including wound infection (27.3%), wound dehiscence (18.2%), reoperation (18.2%), etc. Compared with the pre-enterostomy values, there was a decrease in C-reactive protein (CRP) (P?=?0.001), an increase in albumin (P?=?0.001) and an improvement in the weight-for-age (P?=?0.029) and body mass index (BMI) Z-scores (P?=?0.004) after enterostomy. There was a significant difference between the pre-operation and postoperation medicine expenses (P?=?0.002). Univariate binary logistic regression analysis revealed a statistically significant influence of CRP (OR: 1.43, 95% CI: 1.07–1.91, P?=?0.016) and a tendency towards a significant influence of intestinal perforation, albumin level, BMI Z-score and weighted paediatric Crohn’s disease activity index (wPCDAI). Multivariate logistic regression analysis showed that CRP (OR: 1.40), wPCDAI (OR: 2.88) and perforation (OR: 1.72) showed a tendency to behave as independent risk factors for postoperative complications, but the results were not significant (all P??0.05). Surgery and enterostomy showed benefits for VEOIBD with IL-10 signalling deficiency. The timing of intervention, potential postoperative complications, economic burden and other related problems should be considered.
机译：白细胞介素-10（IL10）信号传导途径缺乏导致严重的早期发作炎症性肠病（Veoibd），肠胃术往往是不可避免的。然而，缺乏这些手术人群的研究。本研究旨在确定肠胃术患者的肠胃术特征，术后并发症和相关危险因素。从2015年3月1日起，到2018年12月31日，招募了接受肠胃术的IL10R-突变的患者进行分析。我们收集了患者临床特征，肠胃术特征，术后并发症和相关危险因素的数据。 12名患者需要急诊肠胃术，10名患者接受选修肠道术。 12名患者经历了术后并发症，包括伤口感染（27.3％），伤口裂开（18.2％），再捕获（18.2％）等与预肠外值相比，C反应蛋白（CRP）减少（ p？= 0.001），白蛋白的增加（p？= 0.001），增量（p≤x0.029）和体重指数（bmi）z分数的改善（p？=？ 0.004）肠胃术后。预制和术后医学费用之间存在显着差异（P？= 0.002）。单变量二元逻辑回归分析显示CRP的统计学显着影响（或：1.43,95％CI：1.07-1.91，P？=？0.016）以及肠穿孔，白蛋白水平，BMI Z评分和趋势的趋势。加权儿科克罗恩病活动指数（WPCDAI）。多变量逻辑回归分析显示CRP（或：1.40），WPCDAI（或：2.88）和穿孔（或：1.72）表现出作为术后并发症的独立危险因素的趋势，但结果并不重要（所有P？> ？0.05）。手术和肠胃术对Veoibd具有IL-10信号传导缺陷的益处。应考虑干预的时间，潜在的术后并发症，经济负担和其他相关问题。

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