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首页> 外文期刊>BMJ Open Respiratory Research >Vimentin as a target for the treatment of COVID-19
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Vimentin as a target for the treatment of COVID-19

机译：作为治疗Covid-19的目标

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We and others propose vimentin as a possible cellular target for the treatment of COVID-19. This innovative idea is so recent that it requires further attention and debate. The significant role played by vimentin in virus-induced infection however is well established: (1) vimentin has been reported as a co-receptor and/or attachment site for SARS-CoV; (2) vimentin is involved in viral replication in cells; (3) vimentin plays a fundamental role in both the viral infection and the consequent explosive immune-inflammatory response and (4) a lower vimentin expression is associated with the inhibition of epithelial to mesenchymal transition and fibrosis. Moreover, the absence of vimentin in mice makes them resistant to lung injury. Since vimentin has a twofold role in the disease, not only being involved in the viral infection but also in the associated life-threatening lung inflammation, the use of vimentin-targeted drugs may offer a synergistic advantage as compared with other treatments not targeting vimentin. Consequently, we speculate here that drugs which decrease the expression of vimentin can be used for the treatment of patients with COVID-19 and advise that several Food and Drug Administration-approved drugs be immediately tested in clinical trials against SARS-CoV-2, thus broadening therapeutic options for this type of viral infection.
机译：我们和其他人将VimentIN作为治疗Covid-19的可能的细胞靶标。这种创新的想法是最近需要进一步关注和辩论。然而，Vimentin在病毒诱导的感染中发挥的显着作用是很好的：（1）Vimentin已被报告为SARS-COV的共同受体和/或附着部位; （2）Vimentin参与细胞中的病毒复制; （3）Vimentin在病毒感染和随后的爆炸性免疫炎症反应中起着基本作用，并且（4）较低的Vimentin表达与抑制上皮性与间充质转变和纤维化有关。此外，小鼠的缺乏导航蛋白使它们抵抗肺损伤。由于Vimentin在疾病中具有两倍的作用，不仅参与病毒感染，而且在相关的危及生命的肺炎中，与不瞄准Vimentin的其他治疗相比，使用Vimentin靶向药物的使用可能提供协同的优势。因此，我们推测，降低Vimentin表达的药物可用于治疗Covid-19患者，并建议在针对SARS-COV-2的临床试验中立即测试几种食物和药物管理局批准的药物，因此拓宽这种病毒感染的治疗选择。

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